Liu Xiao, Bai Jie, Qi Xinrui, Wu Yifan, Ling Jitao, Liu Xinyu, Song Tiangang, Zhang Jing, Yan Zhiwei, Zhang Deju, Yu Peng
Department of Endocrinology Medicine, the Second Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang Jiangxi China.
Department of Cardiology Sun Yat-sen Memorial Hospital of Sun Yat-sen University Guangzhou Guangdong China.
J Am Heart Assoc. 2025 May 6;14(9):e035978. doi: 10.1161/JAHA.124.035978. Epub 2025 Apr 16.
Cardiovascular disease (CVD) presents a significant burden among middle-aged adults (aged 35-64). Diet high in sugar-sweetened beverages is a notable CVD risk factor.
Using Global Burden of Disease data from 1990 to 2019, age-standardized rates (ASRs) and average annual percentage change of ASRs were used to describe this burden and its changing trend.
In 2019, global CVD-related ASR (per 100 000) of deaths attributable to sugar-sweetened beverages in middle-aged adults reached 1.91 (95% uncertainty interval [UI], 1.07-2.63) compared with 2.75 (95% UI, 1.76-3.59) in 1990. The global ASR of disability-adjusted life years (DALYs) reached 69.71 in 2019 (95% UI, 38.38-96.36) compared with 97.98 (95% UI, 62.29-128.39) in 1990. Men had more than twice the deaths and DALYs as women. Low and low-middle sociodemographic index regions exhibited a higher burden of DALYs and deaths. In 2019, India and China had the highest numbers of deaths and DALYs and the Solomon Islands and Afghanistan recorded the highest ASRs of deaths and DALYs. A negative linear correlation was observed between sociodemographic index and ASRs of deaths (=-0.10, =0.010) and DALYs (=-0.09, =0.031) across 21 Global Burden of Disease regions. An inequalities analysis indicated that DALYs due to CVD were disproportionately higher in countries with lower sociodemographic index in 2019 (concentration index of inequality=-0.05 [95% CI, -0.1 to -0.01]).
Globally, sugar-sweetened beverages have contributed to a substantial increase in DALYs and deaths related to CVD in middle-aged adults over the past 30 years, especially among men and in low sociodemographic index countries.
心血管疾病（CVD）在中年成年人（35 - 64岁）中造成了重大负担。高糖饮料的饮食是一个显著的心血管疾病风险因素。
利用1990年至2019年全球疾病负担数据，采用年龄标准化率（ASRs）和ASRs的平均年变化百分比来描述这一负担及其变化趋势。
2019年，中年成年人中与高糖饮料相关的心血管疾病死亡年龄标准化率（每10万人）达到1.91（95%不确定区间[UI]，1.07 - 2.63），而1990年为2.75（95% UI，1.76 - 3.59）。2019年全球残疾调整生命年（DALYs）的年龄标准化率达到69.71（95% UI，38.38 - 96.36），而1990年为97.98（95% UI，62.29 - 128.39）。男性的死亡人数和DALYs是女性的两倍多。社会人口指数低和中低的地区DALYs和死亡负担更高。2019年，印度和中国的死亡人数和DALYs最多，所罗门群岛和阿富汗的死亡和DALYs年龄标准化率最高。在21个全球疾病负担区域中，观察到社会人口指数与死亡年龄标准化率（=-0.10，=0.010）和DALYs（=-0.09，=0.031）之间呈负线性相关。不平等分析表明，2019年社会人口指数较低的国家中，心血管疾病导致的DALYs比例过高（不平等集中指数=-0.05 [95% CI，-0.1至-0.01]）。
在全球范围内，过去30年中，高糖饮料导致中年成年人中与心血管疾病相关的DALYs和死亡人数大幅增加，尤其是在男性和社会人口指数较低的国家。
