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纳米颗粒交流介电泳综述。

A Review on AC-Dielectrophoresis of Nanoparticles.

作者信息

Mondal Tonoy K, Bangaru Aaditya V B, Williams Stuart J

机构信息

Department of Mechanical Engineering, University of Louisville, Louisville, KY 40208, USA.

出版信息

Micromachines (Basel). 2025 Apr 11;16(4):453. doi: 10.3390/mi16040453.

DOI:10.3390/mi16040453
PMID:40283328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12029287/
Abstract

Dielectrophoresis at the nanoscale has gained significant attention in recent years as a low-cost, rapid, efficient, and label-free technique. This method holds great promise for various interdisciplinary applications related to micro- and nanoscience, including biosensors, microfluidics, and nanomachines. The innovation and development of such devices and platforms could promote wider applications in the field of nanotechnology. This review aims to provide an overview of recent developments and applications of nanoparticle dielectrophoresis, where at least one dimension of the geometry or the particles being manipulated is equal to or less than 100 nm. By offering a theoretical foundation to understand the processes and challenges that occur at the nanoscale-such as the need for high field gradients-this article presents a comprehensive overview of the advancements and applications of nanoparticle dielectrophoresis platforms over the past 15 years. This period has been characterized by significant progress, as well as persistent challenges in the manipulation and separation of nanoscale objects. As a foundation for future research, this review will help researchers explore new avenues and potential applications across various fields.

摘要

近年来,纳米级介电泳作为一种低成本、快速、高效且无标记的技术受到了广泛关注。这种方法在与微纳科学相关的各种跨学科应用中具有巨大潜力,包括生物传感器、微流体和纳米机器。此类设备和平台的创新与发展能够推动纳米技术领域更广泛的应用。本综述旨在概述纳米颗粒介电泳的最新进展和应用,其中被操控的几何形状或颗粒的至少一个维度等于或小于100纳米。通过提供理论基础以理解纳米尺度下发生的过程和挑战,例如对高场梯度的需求,本文全面概述了过去15年中纳米颗粒介电泳平台的进展和应用。这一时期取得了显著进展,但在纳米级物体的操控和分离方面也存在持续挑战。作为未来研究的基础,本综述将帮助研究人员探索各个领域的新途径和潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/12029287/c5359ee42415/micromachines-16-00453-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/12029287/c373fc5032d4/micromachines-16-00453-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/12029287/b70212715c16/micromachines-16-00453-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/12029287/8bc14bac5b4f/micromachines-16-00453-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/12029287/27bcc1a5fc01/micromachines-16-00453-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/12029287/c5359ee42415/micromachines-16-00453-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/12029287/c373fc5032d4/micromachines-16-00453-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/12029287/b70212715c16/micromachines-16-00453-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/12029287/8bc14bac5b4f/micromachines-16-00453-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/12029287/27bcc1a5fc01/micromachines-16-00453-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb44/12029287/c5359ee42415/micromachines-16-00453-g005.jpg

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本文引用的文献

1
Dielectrophoretic Microfluidic Designs for Precision Cell Enrichments and Highly Viable Label-Free Bacteria Recovery from Blood.用于从血液中精确富集细胞和高效回收高活力无标记细菌的介电泳微流控设计。
Micromachines (Basel). 2025 Feb 19;16(2):236. doi: 10.3390/mi16020236.
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Design and Fabrication of Microelectrodes for Dielectrophoresis and Electroosmosis in Microsystems for Bio-Applications.用于生物应用微系统中介电电泳和电渗作用的微电极的设计与制造
Micromachines (Basel). 2025 Feb 7;16(2):190. doi: 10.3390/mi16020190.
3
Dielectrophoresis Tutorial: Inspired by Hatfield's 1924 Patent and Boltzmann's Theory and Experiments of 1874.
介电泳教程:灵感源自哈特菲尔德1924年的专利以及玻尔兹曼1874年的理论与实验。
Electrophoresis. 2025 Mar 6. doi: 10.1002/elps.8114.
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Recent advances in designable nanomaterial-based electrochemical sensors for environmental heavy-metal detection.用于环境重金属检测的可设计纳米材料基电化学传感器的最新进展
Nanoscale. 2025 Jan 29;17(5):2386-2407. doi: 10.1039/d4nr04108a.
5
Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy.金纳米颗粒综述:合成、性质、形状、细胞摄取、靶向性、释放机制以及在药物递送与治疗中的应用
Pharmaceutics. 2024 Oct 16;16(10):1332. doi: 10.3390/pharmaceutics16101332.
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Electrokinetic particle trapping in microfluidic wells using conductive nanofiber mats.使用导电纳米纤维垫在微流控阱中进行电动粒子捕获。
Electrophoresis. 2024 Sep 2. doi: 10.1002/elps.202400051.
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An electrospun nanofiber mat as an electrode for AC-dielectrophoretic trapping of nanoparticles.一种作为用于交流电介电泳捕获纳米颗粒的电极的电纺纳米纤维垫。
Nanoscale. 2023 Nov 23;15(45):18241-18249. doi: 10.1039/d3nr04496c.
8
Dielectrophoretic profiling of erythrocytes to study the impacts of metabolic stress, temperature, and storage duration utilizing a point-and-planar microdevice.利用点-面微流控芯片研究代谢应激、温度和储存时间对红细胞的电泳特性的影响
Sci Rep. 2023 Oct 12;13(1):17281. doi: 10.1038/s41598-023-44022-9.
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Enhancement of dielectrophoresis-based particle collection from high conducting fluids due to partial electrode insulation.由于部分电极绝缘,基于电介质电泳的粒子从高导电性流体中的收集得到增强。
Electrophoresis. 2023 Aug;44(15-16):1234-1246. doi: 10.1002/elps.202200295. Epub 2023 Jul 10.
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On-chip real-time impedance monitoring of hiPSC-derived and artificial basement membrane-supported endothelium.基于 hiPSC 衍生和人工基底膜支持的内皮细胞的片上实时阻抗监测。
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