Chan Taylor C, Heacock Elisa, Cournoyer Ashleigh, Walsh Koranda, Durham Amy C
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA.
Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA.
JFMS Open Rep. 2025 Apr 16;11(1):20551169251325333. doi: 10.1177/20551169251325333. eCollection 2025 Jan-Jun.
A 6-year-old female spayed domestic shorthair cat was presented for abdominal distension and weight loss. Abdominal radiographs and ultrasound revealed two cranial abdominal masses and another mass adjacent to the jejunum. Cytologic features of the cranial abdominal masses were consistent with exocrine pancreatic tissue. Four months later, a repeat abdominal ultrasound revealed progressive enlargement of the abdominal masses and medial iliac lymphadenopathy. On exploratory laparotomy, two abdominal masses were associated with the pancreas and incorporated large blood vessels supplying the liver, pancreas and spleen. The masses were non-resectable and incisional biopsies were obtained. The histologic features were diagnostic for a hyalinizing subtype of exocrine pancreatic adenocarcinoma. Chemotherapy was not pursued. Over 28 months after the initial detection of abdominal masses, the cat was still alive and reportedly doing well.
To the authors' knowledge, this is the first report of a hyalinizing subtype of pancreatic adenocarcinoma in a cat. This subtype is considered to behave less aggressively in dogs, and this case may support that a similar, more indolent behavior may be seen in cats.
一只6岁已绝育的雌性家养短毛猫因腹胀和体重减轻前来就诊。腹部X光片和超声检查发现腹部有两个肿块位于颅侧，另一个肿块位于空肠附近。颅侧腹部肿块的细胞学特征与外分泌胰腺组织一致。四个月后，再次进行腹部超声检查显示腹部肿块逐渐增大，髂内侧淋巴结病。在剖腹探查术中，发现两个腹部肿块与胰腺有关，并包含供应肝脏、胰腺和脾脏的大血管。这些肿块无法切除，于是进行了切开活检。组织学特征诊断为外分泌胰腺腺癌的透明变性亚型。未进行化疗。在最初发现腹部肿块28个月后，这只猫仍然存活，据报道状况良好。
据作者所知，这是猫胰腺腺癌透明变性亚型的首例报告。这种亚型在犬中被认为侵袭性较小，该病例可能支持在猫中也会出现类似的、更惰性的行为。
