Upaphong Phit, Tananuvat Napaporn, Niparugs Muanploy, Choovuthayakorn Janejit, Tangmonkongvoragul Chulaluck, Ausayakhun Somsanguan, Chaidaroon Winai
Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Chiang Mai University LASIK Center, Center of Medical Excellence, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Sci Rep. 2025 Apr 28;15(1):14793. doi: 10.1038/s41598-025-00122-2.
Current evidence suggests allergic conjunctivitis and contact lens use may affect corneal biomechanics, but the relationship between conjunctival changes and biomechanical abnormalities remains unclear. This study aimed to determine whether upper tarsal conjunctival roughness and redness are associated with corneal biomechanical weakening in refractive surgery candidates without ectatic corneal disease. Conducted at Chiang Mai University LASIK Center between July 2023 and January 2024, conjunctival roughness and redness were graded using the Institute for Eye Research (IER) scales, while corneal biomechanics were assessed through Corvis parameters. The study included 434 eyes from 217 participants (70.5% female), with a mean age of 33.4 years (SD 8.3). Ocular allergy was reported by 23.0% (50/217) of participants, and 54.4% (236/434) had a history of contact lens use. The median conjunctival roughness score was 2 (IQR 0, 5). Conjunctival roughness score was positively correlated with biomechanical indices, particularly the deformation amplitude (DA) ratio (coefficient 0.009, 95% confidence interval 0.001 to 0.017, p = .04), suggesting weakened biomechanical property. No significant association was found between conjunctival redness and corneal biomechanics. In conclusion, upper tarsal roughness may associate with biomechanical weakening of the cornea, though these changes were insufficient to significantly affect the Corvis Biomechanical Index (CBI).
目前的证据表明，过敏性结膜炎和隐形眼镜的使用可能会影响角膜生物力学，但结膜变化与生物力学异常之间的关系仍不清楚。本研究旨在确定在没有角膜扩张性疾病的屈光手术候选者中，上睑结膜粗糙度和发红是否与角膜生物力学减弱有关。2023年7月至2024年1月在清迈大学准分子激光原位角膜磨镶术（LASIK）中心进行，结膜粗糙度和发红程度采用眼研究学会（IER）量表进行分级，而角膜生物力学则通过Corvis参数进行评估。该研究纳入了217名参与者的434只眼（女性占70.5%），平均年龄为33.4岁（标准差8.3）。23.0%（50/217）的参与者报告有眼部过敏，54.4%（236/434）有隐形眼镜使用史。结膜粗糙度评分中位数为2（四分位间距0，5）。结膜粗糙度评分与生物力学指标呈正相关，尤其是变形幅度（DA）比值（系数0.009，95%置信区间0.001至0.017，p = 0.04），提示生物力学性能减弱。未发现结膜发红与角膜生物力学之间存在显著关联。总之，上睑粗糙度可能与角膜生物力学减弱有关，尽管这些变化不足以显著影响Corvis生物力学指数（CBI）。
