Usuki S, Saito M, Miyagawa S, Iwasaki H
Jpn J Antibiot. 1985 Apr;38(4):921-5.
We made fundamental and clinical studies of a new cephalosporin derivative, cefpimizole (AC-1370). AC-1370 was relatively efficiently transferred into the uterine adnexa; in other words, it was as well transferred into the tissues as the other cephalosporin derivatives. There seemed to be no specific relation between its blood level and its level in any tissue. In 1 patient treated with AC-1370 for postoperative infection, clinical findings, WBC and CRP improved: the drug was evaluated as effective. Neither hepatic nor renal function was impaired in the patients treated with AC-1370 in the fundamental and clinical studies of the drug.
我们对一种新型头孢菌素衍生物头孢咪唑（AC - 1370）进行了基础和临床研究。AC - 1370相对有效地转移至子宫附件；换言之，它与其他头孢菌素衍生物一样能很好地转移至组织中。其血药浓度与任何组织中的浓度之间似乎没有特定关系。在1例接受AC - 1370治疗术后感染的患者中，临床症状、白细胞计数和C反应蛋白均有改善：该药物被评估为有效。在该药物的基础和临床研究中，接受AC - 1370治疗的患者肝功能和肾功能均未受损。
