一种能在猴细胞上高效增殖的人腺病毒2型变体的分离。
Isolation of a variant of human adenovirus serotype 2 that multiplies efficiently on monkey cells.
作者信息
Klessig D F
出版信息
J Virol. 1977 Mar;21(3):1243-6. doi: 10.1128/JVI.21.3.1243-1246.1977.
Abstract
A variant of adenovirus serotype 2 (Ad2) that overcomes the block to multiplication of the wild-type Ad2 on monkey cells is described. The variant was selected, after nitrous acid mutagenesis, by sequential passage on monkey cells. This variant forms plaques with similar efficiency on human and monkey cells cells. The kinetics of its growth and its burst size on human and monkey cells are similar. These growth properties are similar to those found for wild-type Ad2 on monkey cells when the block is overcome by coinfection with simian virus 40.
摘要
本文描述了一种腺病毒2型（Ad2）变体，该变体克服了野生型Ad2在猴细胞上增殖的障碍。该变体是在亚硝酸诱变后，通过在猴细胞上连续传代筛选得到的。此变体在人细胞和猴细胞上形成噬斑的效率相似。其在人细胞和猴细胞上的生长动力学及爆发量相似。当通过与猿猴病毒40共感染克服障碍时，这些生长特性与野生型Ad2在猴细胞上的生长特性相似。
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