Sun Ming, Cheng Lidi, Xu Zexian, Chen Liqiang, Liu Yanshan, Xu Yaoxiang, Zhou Dongyang, Zhang Xiuxiu, Zhou Qihui, Sun Jian
The Affiliated Hospital of Qingdao University, Qingdao, China.
School of Stomatology of Qingdao University, Qingdao, China.
Front Bioeng Biotechnol. 2022 Feb 8;10:826971. doi: 10.3389/fbioe.2022.826971. eCollection 2022.
This study aims to explore the feasibility of the novel temperature-sensitive hydrogel-based dual sustained-release system (Van/SBA-15/CS-GP-SA) in the repair and treatment of infectious jaw defects. Van/SBA-15 was prepared using the mesoporous silica (SBA-15) as a carrier for vancomycin hydrochloride (Van), and Van/SBA-15 was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectrometry (EDS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR), Brunauer-Emmett-Teller (BET), and Barrett-Joyner-Halenda (BJH). The characterization results confirm that Van is loaded in SBA-15 successfully. Van/SBA-15/CS-GP-SA is constructed by encapsulating Van/SBA-15 in chitosan-sodium glycerophosphate-sodium alginate hydrogel (CS-GP-SA). The microstructures, sustained-release ability, biocompatibility, and antibacterial properties of Van/SBA-15/CS-GP-SA were systematically studied. Van/SBA-15/CS-GP-SA is found to have promising sustained-release ability, outstanding biocompatibility, and excellent antibacterial properties. This study provides new ideas for the management of infectious jaw defects.
本研究旨在探讨新型温度敏感水凝胶基双重缓释系统（Van/SBA-15/CS-GP-SA）在感染性颌骨缺损修复治疗中的可行性。以介孔二氧化硅（SBA-15）为盐酸万古霉素（Van）的载体，制备了Van/SBA-15，并通过扫描电子显微镜（SEM）、透射电子显微镜（TEM）、能谱分析（EDS）、X射线光电子能谱（XPS）、傅里叶变换红外光谱（FTIR）、布鲁诺尔-埃米特-泰勒（BET）和巴雷特-乔伊纳-哈伦达（BJH）对其进行了表征。表征结果证实Van成功负载于SBA-15中。通过将Van/SBA-15包裹于壳聚糖-甘油磷酸钠-海藻酸钠水凝胶（CS-GP-SA）中构建了Van/SBA-15/CS-GP-SA。对Van/SBA-15/CS-GP-SA的微观结构、缓释能力、生物相容性和抗菌性能进行了系统研究。发现Van/SBA-15/CS-GP-SA具有良好的缓释能力、出色的生物相容性和优异的抗菌性能。本研究为感染性颌骨缺损的治疗提供了新思路。
