Frost L, Johansen P, Pedersen S, Veien N, Ostergaard P A, Nielsen M H
Allergy. 1985 Jul;40(5):368-72. doi: 10.1111/j.1398-9995.1985.tb00249.x.
A follow-up study of 202 children who had received hyposensitization with aluminium-containing allergens showed that 1-3 years after cessation of hyposensitization 13 children still had severely pruiginous treatment-resistant subcutaneous nodules in their forearms. Because of their long persistence the nodules of six children were studied in detail. Histologically, the nodules showed infiltration with lymphocytes (forming germinal centres), macrophages, plasma cells, mast cells and a few eosinophils. In five patients aluminium crystals were found scattered between the cells and, in addition, the phagosomes of the macrophages contained aluminium. Patch tests for aluminium were positive in four of the six patients. It is concluded that persisting nodules during hyposensitization with aluminium-containing allergens may indicate development of aluminium hypersensitivity, and if this is confirmed hyposensitization should be discontinued.
一项对202名接受含铝过敏原减敏治疗的儿童的随访研究表明，在减敏治疗停止1至3年后，13名儿童的前臂仍有严重瘙痒且对治疗有抵抗性的皮下结节。由于其中6名儿童的结节持续时间较长，因此对其进行了详细研究。组织学检查显示，结节有淋巴细胞浸润（形成生发中心）、巨噬细胞、浆细胞、肥大细胞和少量嗜酸性粒细胞。在5名患者中，发现铝晶体散在于细胞之间，此外，巨噬细胞的吞噬体中含有铝。6名患者中有4名的铝斑贴试验呈阳性。结论是，在用含铝过敏原进行减敏治疗期间持续存在的结节可能表明发生了铝超敏反应，如果得到证实，应停止减敏治疗。
