母体血液、脐带血和母乳中的铅浓度。
Concentrations of lead in maternal blood, cord blood, and breast milk.
作者信息
Ong C N, Phoon W O, Law H Y, Tye C Y, Lim H H
出版信息
Arch Dis Child. 1985 Aug;60(8):756-9. doi: 10.1136/adc.60.8.756.
Abstract
Lead concentrations in maternal blood, umbilical cord blood, and breast milk from 114 women who were not occupationally exposed to lead were determined by graphite atomic absorption spectrophotometry. The mean concentrations of lead in maternal blood, umbilical cord blood and breast milk were 0.7, 0.55, and 0.23 mumol/l, respectively. A significant correlation was observed between maternal and umbilical cord blood (r = 0.63). A lower correlation was noted between maternal blood and breast milk (r = 0.29). These results suggest that lead freely crosses the placental barrier from mother to fetus and the transfer of this heavy metal from maternal tissues to breast milk is possible, but the metabolic mechanisms are more complicated. In addition, a longitudinal study was conducted of concentrations of lead in breast milk in nine lactating women. Results suggested no significant change in the content of lead in breast milk during early lactation.
摘要
采用石墨原子吸收分光光度法测定了114名非职业性接触铅的女性的母血、脐带血和母乳中的铅浓度。母血、脐带血和母乳中铅的平均浓度分别为0.7、0.55和0.23μmol/L。母血和脐带血之间存在显著相关性（r = 0.63）。母血和母乳之间的相关性较低（r = 0.29）。这些结果表明，铅可自由通过胎盘屏障从母亲转移至胎儿，这种重金属从母体组织转移至母乳是可能的，但代谢机制更为复杂。此外，对9名哺乳期女性的母乳铅浓度进行了纵向研究。结果表明，哺乳早期母乳中的铅含量无显著变化。
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本文引用的文献
1
WHO collaborative breast feeding study. II. Levels of lead and cadmium in Swedish human milk, 1978-1979.
Acta Paediatr Scand. 1981;70(3):281-4. doi: 10.1111/j.1651-2227.1981.tb16552.x.
2
Factors affecting the duration of breast feeding: 1. Measurement of breast milk intake in the first week of life.影响母乳喂养持续时间的因素：1. 出生后第一周母乳摄入量的测定。
Early Hum Dev. 1983 Mar;8(1):49-54. doi: 10.1016/0378-3782(83)90033-6.
3
Lead concentrations of milk, blood, and hair in lactating women.哺乳期妇女乳汁、血液和头发中的铅浓度。
Int Arch Occup Environ Health. 1984;53(3):181-7. doi: 10.1007/BF00398812.
4
Perinatal lead and cadmium burden in a British urban population.英国城市人口围产期铅和镉负荷情况
Arch Dis Child. 1984 Jan;59(1):36-9. doi: 10.1136/adc.59.1.36.
5
Lead in neonates and mothers.新生儿和母亲体内的铅。
Clin Chim Acta. 1983 Oct 31;134(1-2):35-49. doi: 10.1016/0009-8981(83)90182-1.
6
Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon.系统性红斑狼疮：人血清中存在一种异常的酸不稳定白细胞干扰素。
Science. 1982 Apr 23;216(4544):429-31. doi: 10.1126/science.6176024.
7
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J Dairy Sci. 1971 Jul;54(7):1001-5. doi: 10.3168/jds.S0022-0302(71)85962-3.
8
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