2-脱氧葡萄糖、α-甲基葡萄糖苷和氨基葡萄糖对寄生曲霉产生黄曲霉毒素的影响。

Effect of 2-deoxyglucose, alpha-methylglucoside, and glucosamine on aflatoxin production by Aspergillus parasiticus.

作者信息

Buchanan R L, Ocker L A, Stahl H G

出版信息

Arch Microbiol. 1985 Jul;142(2):200-3. doi: 10.1007/BF00447068.

Abstract

The effects of 2-deoxyglucose (2-DOG), alpha-methylglucoside (alpha-MG), and glucosamine (GA) on aflatoxin production by Aspergillus parasiticus were studied using conidia-initiated and replacement cultures. In conidia-initiated, 2-DOG, alpha-MG, and GA supported varying amounts of growth when employed as sole carbon sources. In both conidia-initiated and replacement cultures, 2-DOG, but not alpha-MG nor GA, as sole carbon sources support toxin formation. None of the compounds inhibited aflatoxin production when used in combination with glucose. It appears that neither 2-DOG, alpha-MG, nor GA can be considered nonmetabolizable analogs of glucose in A. parasiticus.

摘要

使用分生孢子起始培养和替代培养研究了2-脱氧葡萄糖（2-DOG）、α-甲基葡萄糖苷（α-MG）和氨基葡萄糖（GA）对寄生曲霉产生黄曲霉毒素的影响。在分生孢子起始培养中，当2-DOG、α-MG和GA用作唯一碳源时，它们支持不同程度的生长。在分生孢子起始培养和替代培养中，作为唯一碳源的2-DOG支持毒素形成，而α-MG和GA则不支持。当这些化合物与葡萄糖联合使用时，均未抑制黄曲霉毒素的产生。看来在寄生曲霉中，2-DOG、α-MG和GA都不能被视为葡萄糖的不可代谢类似物。