Appleton J A, McGregor D D
Immunology. 1985 Jun;55(2):225-32.
Rat dams infected with 1000 Trichinella spiralis muscle larvae, 4 weeks prior to breeding, provided their suckling offspring with immunity to challenge with 200 muscle larvae at 2 weeks of age. The immunity was expressed in the elimination of 75-99% of the challenge dose within 24 hr. The intestinal worm burden did not decline significantly after the initial expulsion. Infected dams continued to protect their offspring during three breeding cycles, for as long as 26 weeks after infection. Immunity was conferred upon pups by dams that had been selectively immunized with the parenteral phase of the parasite's life cycle. Immunization with a drug-terminated enteral infection was ineffective as was enteral immunization followed by the parenteral phase. Further analysis revealed that rapid expulsion by pups was dependent on the number of mature muscle larvae recovered from dams immunized with NBL. By comparison, the expulsive capacity of the same dams was not improved by increasing the numbers of NBL within the range tested.
在繁殖前4周感染1000条旋毛虫肌幼虫的大鼠母鼠，为其哺乳的后代提供了对2周龄时200条肌幼虫攻击的免疫力。这种免疫力表现为在24小时内清除75%-99%的攻击剂量。初次排出后，肠道蠕虫负荷并未显著下降。受感染的母鼠在三个繁殖周期内持续保护其后代，长达感染后26周。通过用寄生虫生命周期的肠外阶段进行选择性免疫的母鼠可将免疫力赋予幼崽。用药物终止肠内感染进行免疫无效，肠内免疫后再进行肠外阶段免疫也无效。进一步分析表明，幼崽的快速排出取决于从用NBL免疫的母鼠中回收的成熟肌幼虫数量。相比之下，在测试范围内增加NBL数量并不能提高相同母鼠的排出能力。
