• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

私有数据增量:用于临床肝脏分割的以数据为中心的模型开发

Private Data Incrementalization: Data-Centric Model Development for Clinical Liver Segmentation.

作者信息

Batista Stephanie, Couceiro Miguel, Filipe Ricardo, Rachinhas Paulo, Isidoro Jorge, Domingues Inês

机构信息

Polytechnic University of Coimbra, Rua da Misericórdia, Lagar dos Cortiços, S. Martinho do Bispo, 3045-093 Coimbra, Portugal.

Institute of Applied Research (i2A), 3045-093 Coimbra, Portugal.

出版信息

Bioengineering (Basel). 2025 May 15;12(5):530. doi: 10.3390/bioengineering12050530.

DOI:10.3390/bioengineering12050530
PMID:40428149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12108710/
Abstract

Machine Learning models, more specifically Artificial Neural Networks, are transforming medical imaging by enabling precise liver segmentation, a crucial task for diagnosing and treating liver diseases. However, these models often face challenges in adapting to diverse clinical data sources as differences in dataset volume, resolution, and origin impact generalization and performance. This study introduces a , a data-centric approach to enhance the adaptability of Artificial Neural Networks by progressively exposing them to varied clinical data. As the target of this study is not to propose a new image segmentation model, the existing medical imaging segmentation models-including U-Net, ResUNet++, Fully Convolutional Network, and a modified algorithm based on the Conditional Bernoulli Diffusion Model-are used. The study evaluates these four models using a curated private dataset of computed tomography scans from Coimbra University Hospital, supplemented by two public datasets, 3D-IRCADb01 and CHAOS. The method systematically increases the volume and diversity of training data, simulating real-world conditions where models must handle varied imaging contexts. Pre-processing and post-processing stages, incremental training, and performance evaluations reveal that structured exposure to diverse datasets improves segmentation performance, with ResUNet++ achieving the highest accuracy (0.9972) and Dice Similarity Coefficient (0.9449), and the best Average Symmetric Surface Distance (0.0053 mm), demonstrating the importance of dataset diversity and volume for segmentation models' robustness and generalization. thus offers a scalable strategy for building resilient segmentation models, ultimately benefiting clinical workflows, patient care, and healthcare resource management by addressing the variability inherent in clinical imaging data.

摘要

机器学习模型,更具体地说是人工神经网络,正在通过实现精确的肝脏分割来改变医学成像,这是诊断和治疗肝脏疾病的一项关键任务。然而,这些模型在适应不同的临床数据源时往往面临挑战,因为数据集的体积、分辨率和来源的差异会影响泛化能力和性能。本研究引入了一种以数据为中心的方法,通过逐步让人工神经网络接触各种临床数据来提高其适应性。由于本研究的目标不是提出一种新的图像分割模型,因此使用了现有的医学成像分割模型,包括U-Net、ResUNet++、全卷积网络以及基于条件伯努利扩散模型的改进算法。该研究使用来自科英布拉大学医院的精心策划的计算机断层扫描私人数据集,并辅以两个公共数据集3D-IRCADb01和CHAOS,对这四种模型进行评估。该方法系统地增加了训练数据的体积和多样性,模拟了模型必须处理各种成像情况的现实世界条件。预处理和后处理阶段、增量训练以及性能评估表明,有组织地接触不同的数据集可以提高分割性能,ResUNet++达到了最高的准确率(0.9972)和骰子相似系数(0.9449),以及最佳的平均对称表面距离(0.0053毫米),证明了数据集多样性和体积对于分割模型的稳健性和泛化能力的重要性。因此,该方法提供了一种构建弹性分割模型的可扩展策略,最终通过解决临床成像数据中固有的变异性,使临床工作流程、患者护理和医疗资源管理受益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/babbafa6a304/bioengineering-12-00530-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/45cc42690a5c/bioengineering-12-00530-g0A1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/3eb8ccff7aba/bioengineering-12-00530-g0A2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/f594bcf1d8c4/bioengineering-12-00530-g0A3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/2a8ab166b7ec/bioengineering-12-00530-g0A4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/21fc8dee5cf7/bioengineering-12-00530-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/747d9951cfcf/bioengineering-12-00530-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/e0c1cc6f38b7/bioengineering-12-00530-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/e78880a3deb1/bioengineering-12-00530-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/c4c743f92e0b/bioengineering-12-00530-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/54ea9cc21ccf/bioengineering-12-00530-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/d933b0465eee/bioengineering-12-00530-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/708710798232/bioengineering-12-00530-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/db10828bf87e/bioengineering-12-00530-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/958948a9edb4/bioengineering-12-00530-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/2f0bf3066fef/bioengineering-12-00530-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/62463eaf6f65/bioengineering-12-00530-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/babbafa6a304/bioengineering-12-00530-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/45cc42690a5c/bioengineering-12-00530-g0A1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/3eb8ccff7aba/bioengineering-12-00530-g0A2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/f594bcf1d8c4/bioengineering-12-00530-g0A3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/2a8ab166b7ec/bioengineering-12-00530-g0A4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/21fc8dee5cf7/bioengineering-12-00530-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/747d9951cfcf/bioengineering-12-00530-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/e0c1cc6f38b7/bioengineering-12-00530-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/e78880a3deb1/bioengineering-12-00530-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/c4c743f92e0b/bioengineering-12-00530-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/54ea9cc21ccf/bioengineering-12-00530-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/d933b0465eee/bioengineering-12-00530-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/708710798232/bioengineering-12-00530-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/db10828bf87e/bioengineering-12-00530-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/958948a9edb4/bioengineering-12-00530-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/2f0bf3066fef/bioengineering-12-00530-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/62463eaf6f65/bioengineering-12-00530-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba6/12108710/babbafa6a304/bioengineering-12-00530-g013.jpg

相似文献

1
Private Data Incrementalization: Data-Centric Model Development for Clinical Liver Segmentation.私有数据增量:用于临床肝脏分割的以数据为中心的模型开发
Bioengineering (Basel). 2025 May 15;12(5):530. doi: 10.3390/bioengineering12050530.
2
Brain tumor segmentation and detection in MRI using convolutional neural networks and VGG16.使用卷积神经网络和VGG16在磁共振成像(MRI)中进行脑肿瘤分割与检测
Cancer Biomark. 2025 Mar;42(3):18758592241311184. doi: 10.1177/18758592241311184. Epub 2025 Apr 4.
3
Vessel segmentation from volumetric images: a multi-scale double-pathway network with class-balanced loss at the voxel level.容积图像中的血管分割:一种基于体素级类别平衡损失的多尺度双通道网络。
Med Phys. 2021 Jul;48(7):3804-3814. doi: 10.1002/mp.14934. Epub 2021 May 31.
4
Automatic liver segmentation by integrating fully convolutional networks into active contour models.基于全卷积网络的主动轮廓模型自动肝脏分割
Med Phys. 2019 Oct;46(10):4455-4469. doi: 10.1002/mp.13735. Epub 2019 Aug 16.
5
Two-stage deep learning model for fully automated pancreas segmentation on computed tomography: Comparison with intra-reader and inter-reader reliability at full and reduced radiation dose on an external dataset.基于 CT 的全自动胰腺分割的两阶段深度学习模型:在外部数据集上比较全剂量和低剂量下的同读者和异读者可靠性。
Med Phys. 2021 May;48(5):2468-2481. doi: 10.1002/mp.14782. Epub 2021 Mar 16.
6
Layered deep learning for automatic mandibular segmentation in cone-beam computed tomography.基于分层深度学习的锥形束计算机断层扫描下颌骨自动分割。
J Dent. 2021 Nov;114:103786. doi: 10.1016/j.jdent.2021.103786. Epub 2021 Aug 20.
7
A novel adaptive cubic quasi-Newton optimizer for deep learning based medical image analysis tasks, validated on detection of COVID-19 and segmentation for COVID-19 lung infection, liver tumor, and optic disc/cup.一种用于深度学习的新型自适应三次拟牛顿优化器,在 COVID-19 检测和 COVID-19 肺部感染、肝脏肿瘤以及视盘/杯分割等医学图像分析任务中得到验证。
Med Phys. 2023 Mar;50(3):1528-1538. doi: 10.1002/mp.15969. Epub 2022 Oct 6.
8
Semi-supervised abdominal multi-organ segmentation by object-redrawing.通过对象重绘实现半监督腹部多器官分割
Med Phys. 2024 Nov;51(11):8334-8347. doi: 10.1002/mp.17364. Epub 2024 Aug 21.
9
[Fully Automatic Glioma Segmentation Algorithm of Magnetic Resonance Imaging Based on 3D-UNet With More Global Contextual Feature Extraction: An Improvement on Insufficient Extraction of Global Features].基于具有更多全局上下文特征提取的3D-UNet的磁共振成像全自动胶质瘤分割算法:对全局特征提取不足的改进
Sichuan Da Xue Xue Bao Yi Xue Ban. 2024 Mar 20;55(2):447-454. doi: 10.12182/20240360208.
10
An application of cascaded 3D fully convolutional networks for medical image segmentation.级联三维全卷积网络在医学图像分割中的应用。
Comput Med Imaging Graph. 2018 Jun;66:90-99. doi: 10.1016/j.compmedimag.2018.03.001. Epub 2018 Mar 16.

本文引用的文献

1
TransUNet: Rethinking the U-Net architecture design for medical image segmentation through the lens of transformers.TransUNet:通过Transformer 的视角重新思考医学图像分割中的 U-Net 架构设计。
Med Image Anal. 2024 Oct;97:103280. doi: 10.1016/j.media.2024.103280. Epub 2024 Jul 22.
2
Large-Kernel Attention for 3D Medical Image Segmentation.用于3D医学图像分割的大内核注意力机制
Cognit Comput. 2024;16(4):2063-2077. doi: 10.1007/s12559-023-10126-7. Epub 2023 Feb 27.
3
DA-TransUNet: integrating spatial and channel dual attention with transformer U-net for medical image segmentation.
DA-TransUNet:将空间和通道双重注意力与Transformer U-Net相结合用于医学图像分割
Front Bioeng Biotechnol. 2024 May 16;12:1398237. doi: 10.3389/fbioe.2024.1398237. eCollection 2024.
4
USFM: A universal ultrasound foundation model generalized to tasks and organs towards label efficient image analysis.USFM:一种通用的超声基础模型,可推广到任务和器官,实现高效的标签图像分析。
Med Image Anal. 2024 Aug;96:103202. doi: 10.1016/j.media.2024.103202. Epub 2024 May 15.
5
Multi-attention fusion transformer for single-image super-resolution.用于单图像超分辨率的多注意力融合变压器
Sci Rep. 2024 May 3;14(1):10222. doi: 10.1038/s41598-024-60579-5.
6
Algorithms for Liver Segmentation in Computed Tomography Scans: A Historical Perspective.肝脏 CT 扫描的分割算法:历史透视。
Sensors (Basel). 2024 Mar 8;24(6):1752. doi: 10.3390/s24061752.
7
A statistical deformation model-based data augmentation method for volumetric medical image segmentation.一种基于统计变形模型的容积医学图像分割数据增强方法。
Med Image Anal. 2024 Jan;91:102984. doi: 10.1016/j.media.2023.102984. Epub 2023 Oct 7.
8
Foundation models for generalist medical artificial intelligence.通用型医学人工智能的基础模型。
Nature. 2023 Apr;616(7956):259-265. doi: 10.1038/s41586-023-05881-4. Epub 2023 Apr 12.
9
Prostate Cancer Aggressiveness Prediction Using CT Images.利用CT图像预测前列腺癌侵袭性
Life (Basel). 2021 Oct 31;11(11):1164. doi: 10.3390/life11111164.
10
Domain Adaptation for Medical Image Analysis: A Survey.医学图像分析中的域自适应:综述。
IEEE Trans Biomed Eng. 2022 Mar;69(3):1173-1185. doi: 10.1109/TBME.2021.3117407. Epub 2022 Feb 18.