Wike-Hooley J L, van den Berg A P, van der Zee J, Reinhold H S
Eur J Cancer Clin Oncol. 1985 Jul;21(7):785-91. doi: 10.1016/0277-5379(85)90216-0.
The variation in human tumour pH values is large. The aim of this study was to analyse the reasons for these large variations and to determine whether tumour pH can be predicted on the basis of any easily measured parameter. One hundred and five determinations of tumour pH were performed in various human tumours, using the Philips C 902S tissue pH electrode. No correlations were found between the tumour pH and the tumour histology, degree of differentiation, tumour size, patient age or treatment history, and whether or not the tumour was ulcerated. However, tumour pH was significantly lower in primary tumours than in lymph node metastases. Tumours at their primary site (primary, recurrent or residual) were also more acid than distant metastases. The vascular disruption caused by the measuring technique was found to be acceptable.
人类肿瘤的pH值变化很大。本研究的目的是分析这些巨大变化的原因，并确定是否可以根据任何易于测量的参数来预测肿瘤pH值。使用飞利浦C 902S组织pH电极，对各种人类肿瘤进行了105次肿瘤pH值测定。未发现肿瘤pH值与肿瘤组织学、分化程度、肿瘤大小、患者年龄或治疗史以及肿瘤是否溃疡之间存在相关性。然而，原发性肿瘤的pH值显著低于淋巴结转移瘤。原发部位（原发、复发或残留）的肿瘤也比远处转移瘤更酸。测量技术引起的血管破坏被认为是可以接受的。
