人类乳腺癌中的肿瘤pH值
Tumour pH in human mammary carcinoma.
作者信息
van den Berg A P, Wike-Hooley J L, van den Berg-Blok A E, van der Zee J, Reinhold H S
出版信息
Eur J Cancer Clin Oncol. 1982 May;18(5):457-62. doi: 10.1016/0277-5379(82)90114-6.
Human tumour pH was investigated using the new Philips C902S tissue pH electrode. In 22 mammary carcinomas a pH of 7.29 +/- 0.050 (S.E.M.) was observed, whereas in the human subcutis this value was 7.63 +/- 0.034. Tumour pH in some experimental rat tumours was slightly lower than in humans, 7.15 +/- 0.029 in rhabdomyosarcoma BA1112 and 7.07 +/- 0.024 in a small group of other miscellaneous rat tumours. Rat skeletal muscle was found to have a pH of 7.59 +/- 0.070. It is concluded that a small but highly significant (P less than 0.0001) pH difference exists between human mammary carcinoma and human subcutis. This difference is smaller than expected on the basis of animal studies.
使用新型飞利浦C902S组织pH电极对人类肿瘤的pH值进行了研究。在22例乳腺癌中，观察到pH值为7.29±0.050（标准误），而在人类皮下组织中该值为7.63±0.034。一些实验性大鼠肿瘤的肿瘤pH值略低于人类，横纹肌肉瘤BA1112为7.15±0.029，一小群其他杂类大鼠肿瘤为7.07±0.024。发现大鼠骨骼肌的pH值为7.59±0.070。得出的结论是，人类乳腺癌与人类皮下组织之间存在微小但高度显著（P<0.0001）的pH差异。这种差异比基于动物研究预期的要小。
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