• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

铜掺杂氧化锌纳米粒子的微波辅助绿色合成、密度泛函理论模拟及生物活性评价整合

Integrating microwave-assisted green synthesis, DFT simulations, and biological activity evaluation of copper-doped zinc oxide nanoparticles.

作者信息

M Abisha Meji, D Usha, B M Ashwin, Dennison Milon Selvam

机构信息

Department of Physics and Research Centre, Women's Christian College, Nagercoil, Affiliated to Manonmaniam Sundaranar University, Tirunelveli, India.

PG Department of Chemistry, Pioneer Kumaraswamy College, Nagercoil, India.

出版信息

Sci Rep. 2025 Jun 2;15(1):19348. doi: 10.1038/s41598-025-03922-8.

DOI:10.1038/s41598-025-03922-8
PMID:40456814
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12130543/
Abstract

The advancement of nanotechnology and the growing demand for environmentally sustainable processes have fueled interest in green synthesis methods. In this research, copper-doped zinc oxide nanoparticles (Cu: ZnO NPs) were synthesized using a microwave-assisted approach, employing a bio-extract derived from Pistia Stratiotes (PS) leaves as a reducing agent. Comprehensive characterization through UV-Visible spectroscopy, PL, FTIR, SEM with EDS, TEM, DLS, XRD and XPS confirmed the formation, optical and structural features of the synthesized NPs. SEM and TEM images revealed spherical and nanorod-like morphologies, with particle sizes ranging from 15 nm to 65 nm and a tendency to agglomerate. Density Functional Theory (DFT) simulations using Quantum Espresso indicated a band gap narrowing to 3.0 eV after copper doping. Biologically, the Cu: ZnO NPs exhibited strong antibacterial activity against Candida albicans (16.3-17.5 mm), Staphylococcus aureus (18.4-21.5 mm), and Escherichia coli (19-21.6 mm). Additionally, the NPs showed promising anticancer potential against SK-MEL-28 melanoma cells, with an IC value of 30.53 µg/mL. Overall, this research demonstrates an eco-friendly and efficient route for fabricating Cu: ZnO NPs with significant antimicrobial and anticancer properties, emphasizing their potential for future biomedical applications.

摘要

纳米技术的进步以及对环境可持续发展工艺的需求不断增加，激发了人们对绿色合成方法的兴趣。在本研究中，采用微波辅助方法合成了铜掺杂氧化锌纳米颗粒（Cu:ZnO NPs），使用从大薸（PS）叶片中提取的生物提取物作为还原剂。通过紫外可见光谱、光致发光、傅里叶变换红外光谱、带能谱的扫描电子显微镜、透射电子显微镜、动态光散射、X射线衍射和X射线光电子能谱进行的综合表征证实了合成纳米颗粒的形成、光学和结构特征。扫描电子显微镜和透射电子显微镜图像显示出球形和纳米棒状形态，粒径范围为15纳米至65纳米，并有团聚趋势。使用量子 espresso 进行的密度泛函理论（DFT）模拟表明，铜掺杂后带隙缩小至3.0电子伏特。在生物学上，Cu:ZnO NPs对白色念珠菌（16.3 - 17.5毫米）、金黄色葡萄球菌（18.4 - 21.5毫米）和大肠杆菌（19 - 21.6毫米）表现出强大的抗菌活性。此外，这些纳米颗粒对SK - MEL - 28黑色素瘤细胞显示出有前景的抗癌潜力，IC值为30.53微克/毫升。总体而言，本研究展示了一种生态友好且高效的路线来制备具有显著抗菌和抗癌特性的Cu:ZnO NPs，强调了它们在未来生物医学应用中的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/bed0e8d638de/41598_2025_3922_Fig20_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/f1440eaf2045/41598_2025_3922_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/167989743e05/41598_2025_3922_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/bf39b5e48bed/41598_2025_3922_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/a3026691ebe2/41598_2025_3922_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/399f94d73c02/41598_2025_3922_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/f77b4c562357/41598_2025_3922_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/4e851f271eee/41598_2025_3922_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/dbd212bc91c7/41598_2025_3922_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/443b1f421355/41598_2025_3922_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/47a2baeefb27/41598_2025_3922_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/a40d54fc8fc7/41598_2025_3922_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/80262c25ce04/41598_2025_3922_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/1716fa7eb681/41598_2025_3922_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/abbc0b6d8210/41598_2025_3922_Fig14_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/967bbdf422db/41598_2025_3922_Fig15_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/134b39af3c66/41598_2025_3922_Fig16_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/9830c11a997f/41598_2025_3922_Fig17_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/7fa870a8891c/41598_2025_3922_Fig18_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/8ab8e253fef3/41598_2025_3922_Fig19_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/bed0e8d638de/41598_2025_3922_Fig20_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/f1440eaf2045/41598_2025_3922_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/167989743e05/41598_2025_3922_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/bf39b5e48bed/41598_2025_3922_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/a3026691ebe2/41598_2025_3922_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/399f94d73c02/41598_2025_3922_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/f77b4c562357/41598_2025_3922_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/4e851f271eee/41598_2025_3922_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/dbd212bc91c7/41598_2025_3922_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/443b1f421355/41598_2025_3922_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/47a2baeefb27/41598_2025_3922_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/a40d54fc8fc7/41598_2025_3922_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/80262c25ce04/41598_2025_3922_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/1716fa7eb681/41598_2025_3922_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/abbc0b6d8210/41598_2025_3922_Fig14_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/967bbdf422db/41598_2025_3922_Fig15_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/134b39af3c66/41598_2025_3922_Fig16_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/9830c11a997f/41598_2025_3922_Fig17_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/7fa870a8891c/41598_2025_3922_Fig18_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/8ab8e253fef3/41598_2025_3922_Fig19_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7c/12130543/bed0e8d638de/41598_2025_3922_Fig20_HTML.jpg

相似文献

1
Integrating microwave-assisted green synthesis, DFT simulations, and biological activity evaluation of copper-doped zinc oxide nanoparticles.铜掺杂氧化锌纳米粒子的微波辅助绿色合成、密度泛函理论模拟及生物活性评价整合
Sci Rep. 2025 Jun 2;15(1):19348. doi: 10.1038/s41598-025-03922-8.
2
Eco-friendly synthesis of ZnO nanoparticles fabricated using Fioria vitifolia L. and their biomedical potentials.利用费奥里叶（Fioria vitifolia L.）进行氧化锌纳米颗粒的环保合成及其生物医学潜力。
Microb Pathog. 2025 Feb;199:107139. doi: 10.1016/j.micpath.2024.107139. Epub 2024 Nov 22.
3
Green Synthesis of Zinc Oxide Nanoparticles as a Promising Nanomedicine Approach for Anticancer, Antibacterial, and Anti-Inflammatory Therapies.氧化锌纳米颗粒的绿色合成作为一种有前景的纳米医学方法用于抗癌、抗菌和抗炎治疗。
Int J Nanomedicine. 2025 Apr 7;20:4299-4317. doi: 10.2147/IJN.S507214. eCollection 2025.
4
Green route to synthesize Zinc Oxide Nanoparticles using leaf extracts of Cassia fistula and Melia azadarach and their antibacterial potential.绿色路线合成氧化锌纳米粒子使用叶提取物的决明子和楝树和他们的抗菌潜力。
Sci Rep. 2020 Jun 3;10(1):9055. doi: 10.1038/s41598-020-65949-3.
5
Ionic liquid - A greener templating agent with Justicia adhatoda plant extract assisted green synthesis of morphologically improved Ag-Au/ZnO nanostructure and it's antibacterial and anticancer activities.离子液体-一种更环保的模板剂，与辣木叶提取物协同作用，绿色合成形貌改善的Ag-Au/ZnO 纳米结构及其抗菌和抗癌活性。
J Photochem Photobiol B. 2019 Sep;198:111559. doi: 10.1016/j.jphotobiol.2019.111559. Epub 2019 Jul 17.
6
Biosynthesis, characterization and antimicrobial activities of zinc oxide nanoparticles from leaf extract of Mentha pulegium (L.).从薄荷（Mentha pulegium（L.））叶提取物中生物合成、表征和评价氧化锌纳米粒子的抗菌活性。
Microb Pathog. 2019 Jun;131:239-245. doi: 10.1016/j.micpath.2019.04.022. Epub 2019 Apr 17.
7
Eco-friendly synthesis of betanin-conjugated zinc oxide nanoparticles: antimicrobial efficacy and apoptotic pathway activation in oral cancer cells.甜菜碱偶联氧化锌纳米粒子的绿色合成：口腔癌细胞的抗菌功效和凋亡途径激活。
Mol Biol Rep. 2024 Nov 7;51(1):1128. doi: 10.1007/s11033-024-10039-0.
8
Leaf Extract Mediated Synthesis of Zinc Oxide Nanoparticles: Assessment of Antimicrobial and Anticancer Activity.叶片提取物介导的氧化锌纳米粒子的合成：抗菌和抗癌活性评估。
Molecules. 2020 Oct 23;25(21):4896. doi: 10.3390/molecules25214896.
9
Biosynthesis of zinc oxide nanoparticles neem extract and their anticancer and antibacterial activities.用印楝提取物合成氧化锌纳米粒子及其抗癌和抗菌活性。
PeerJ. 2024 Jun 25;12:e17588. doi: 10.7717/peerj.17588. eCollection 2024.
10
In vitro antioxidant and antibacterial activities of biogenic synthesized zinc oxide nanoparticles using leaf extract of Mallotus philippinensis Mull. Arg.利用菲律宾野桐（Mallotus philippinensis Mull. Arg.）叶提取物生物合成氧化锌纳米颗粒的体外抗氧化和抗菌活性
Sci Rep. 2025 Feb 24;15(1):6541. doi: 10.1038/s41598-025-85264-z.

引用本文的文献

1
Machine-Learning-Guided Design of Nanostructured Metal Oxide Photoanodes for Photoelectrochemical Water Splitting: From Material Discovery to Performance Optimization.用于光电化学水分解的纳米结构金属氧化物光阳极的机器学习引导设计：从材料发现到性能优化
Nanomaterials (Basel). 2025 Jun 18;15(12):948. doi: 10.3390/nano15120948.

本文引用的文献

1
Nanotechnology for Healthcare: Plant-Derived Nanoparticles in Disease Treatment and Regenerative Medicine.医疗保健中的纳米技术：植物源纳米颗粒在疾病治疗和再生医学中的应用
Pharmaceuticals (Basel). 2024 Dec 18;17(12):1711. doi: 10.3390/ph17121711.
2
Silver Nanoparticles: Synthesis, Structure, Properties and Applications.银纳米颗粒：合成、结构、性质及应用
Nanomaterials (Basel). 2024 Aug 31;14(17):1425. doi: 10.3390/nano14171425.
3
Metallic nanoparticles unveiled: Synthesis, characterization, and their environmental, medicinal, and agricultural applications.
金属纳米粒子揭秘：合成、表征及其在环境、医药和农业中的应用。
Talanta. 2024 Dec 1;280:126790. doi: 10.1016/j.talanta.2024.126790. Epub 2024 Aug 29.
4
Designing copper-doped zinc oxide nanoparticle by tobacco stem extract-mediated green synthesis for solar cell efficiency and photocatalytic degradation of methylene blue.利用烟草茎提取物介导的绿色合成方法设计铜掺杂氧化锌纳米粒子，以提高太阳能电池的效率和光催化降解亚甲基蓝。
Int J Phytoremediation. 2024 Nov;26(13):2183-2193. doi: 10.1080/15226514.2024.2379605. Epub 2024 Jul 22.
5
Multifunctional assessment of copper-doped ZnO nanoparticles synthesized via gliding arc discharge plasma technique: antioxidant, antibacterial, and photocatalytic performance.通过滑动弧放电等离子体技术合成的铜掺杂氧化锌纳米粒子的多功能评估：抗氧化、抗菌和光催化性能。
Environ Sci Pollut Res Int. 2024 Jul;31(31):43743-43756. doi: 10.1007/s11356-024-34054-7. Epub 2024 Jun 22.
6
Synthesis of nano-crystallite hydroxyapatites in different media and a comparative study for estimation of crystallite size using Scherrer method, Halder-Wagner method size-strain plot, and Williamson-Hall model.在不同介质中合成纳米微晶羟基磷灰石，并使用谢乐法、哈尔德-瓦格纳法尺寸应变图和威廉姆森-霍尔模型对微晶尺寸估计进行比较研究。
Heliyon. 2024 Jan 30;10(3):e25347. doi: 10.1016/j.heliyon.2024.e25347. eCollection 2024 Feb 15.
7
Recent Trends in Biologically Synthesized Metal Nanoparticles and their Biomedical Applications: a Review.生物合成金属纳米粒子的最新趋势及其在生物医学中的应用：综述。
Biol Trace Elem Res. 2024 Jul;202(7):3383-3399. doi: 10.1007/s12011-023-03920-9. Epub 2023 Oct 25.
8
Nanotechnology-General Aspects: A Chemical Reduction Approach to the Synthesis of Nanoparticles.纳米技术——一般方面：一种用于合成纳米颗粒的化学还原方法。
Molecules. 2023 Jun 22;28(13):4932. doi: 10.3390/molecules28134932.
9
Green and sustainable synthesis of nanomaterials: Recent advancements and limitations.纳米材料的绿色与可持续合成：最新进展与局限。
Environ Res. 2023 Aug 15;231(Pt 3):116316. doi: 10.1016/j.envres.2023.116316. Epub 2023 Jun 2.
10
Nanoparticles: Taking a Unique Position in Medicine.纳米颗粒：在医学领域占据独特地位。
Nanomaterials (Basel). 2023 Jan 31;13(3):574. doi: 10.3390/nano13030574.