Hopf G, Böcker R, Neumeier P, Guggenmoos-Holzmann I, Estler C J
Biochem Pharmacol. 1985 Oct 15;34(20):3689-91. doi: 10.1016/0006-2952(85)90232-1.
The influence of tetracycline and doxycycline (10-100 micrograms/g i.v.) on the aggregational state of ribosomes from mouse liver was tested. Both drugs caused a disaggregation of the ribosomes as evidenced by a rise of the monosomes + disomes/polysomes ratio. Tetracycline was much more potent than doxycycline, the minimum effective doses for tetracycline being 10 micrograms/g i.v. as compared to 100 micrograms/g for doxycycline. The results show that tetracycline but not doxycycline at therapeutic dose range may interfere with the protein synthesis of the liver.
测试了四环素和强力霉素（静脉注射10 - 100微克/克）对小鼠肝脏核糖体聚集状态的影响。两种药物均导致核糖体解聚，这可通过单体 + 二聚体/多聚体比例的升高得到证明。四环素比强力霉素的作用更强，四环素的最小有效剂量为静脉注射10微克/克，而强力霉素为100微克/克。结果表明，在治疗剂量范围内，四环素而非强力霉素可能会干扰肝脏的蛋白质合成。
