小鼠对细胞内病原体感染的抵抗力随年龄增长而下降。
Age-related decline in the resistance of mice to infection with intracellular pathogens.
作者信息
Gardner I D, Remington J S
出版信息
Infect Immun. 1977 May;16(2):593-8. doi: 10.1128/iai.16.2.593-598.1977.
Abstract
Resistance to infection with Toxoplasma gondii and Listeria monocytogenes in BALB/c female mice decreased with increasing age. The decrease was apparent as early as 9 months of age and was more marked as the animals aged further. This age-related decline in resistance was not restricted to BALB/c female mice, as male and female mice of the C57BL/6 strain exhibited similar responses. With both pathogens, aged mice showed a more marked susceptibility to the strain of lesser virulence. Transfer of normal serum from old mice to young or old mice before infection with T. gondii resulted in an increased susceptibility to this organism, suggesting the presence of inhibitory factors or the absence of potentiating factors that are present in the serum of young mice.
摘要
BALB/c雌性小鼠对刚地弓形虫和单核细胞增生李斯特菌感染的抵抗力随年龄增长而下降。这种下降早在9月龄时就很明显，并且随着动物年龄的进一步增长而更加显著。这种与年龄相关的抵抗力下降并不局限于BALB/c雌性小鼠，因为C57BL/6品系的雄性和雌性小鼠也表现出类似的反应。对于这两种病原体，老年小鼠对毒力较弱的菌株表现出更明显的易感性。在感染刚地弓形虫之前，将老年小鼠的正常血清转移到年轻或老年小鼠体内，会导致对这种病原体的易感性增加，这表明年轻小鼠血清中存在抑制因子或不存在增强因子。
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