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口说为证：卡波西肉瘤作为未确诊艾滋病的首要线索

The Mouth Tells the Tale: Kaposi Sarcoma as the First Clue to Undiagnosed AIDS.

作者信息

Khan Zaraq R, Jarzynski Jacob, Nasim Urooj, Majeed Imad, Shrestha Riya

机构信息

Infectious Diseases, University of Louisville Hospital, Louisville, USA.

Internal Medicine, University of Louisville Hospital, Louisville, USA.

出版信息

Cureus. 2025 Jun 2;17(6):e85243. doi: 10.7759/cureus.85243. eCollection 2025 Jun.

DOI:10.7759/cureus.85243
PMID:40605901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12221191/
Abstract

Kaposi sarcoma (KS) is a vascular neoplasm associated with human herpesvirus-8 (HHV-8), most commonly seen in individuals with advanced human immunodeficiency virus (HIV)/AIDS. We report the case of a 52-year-old male patient with no known HIV history who presented with a three- to four-month history of worsening sore throat, oral pain, diarrhea, weight loss, and systemic symptoms including night sweats and fatigue. The patient was eventually diagnosed with oral KS based on pathological results. This case highlights KS as a potential initial manifestation of advanced HIV/AIDS and the importance of early recognition and treatment.

摘要

卡波西肉瘤（KS）是一种与人类疱疹病毒8型（HHV-8）相关的血管肿瘤，最常见于晚期人类免疫缺陷病毒（HIV）/艾滋病患者。我们报告了一例52岁男性患者，他无已知HIV病史，出现了三到四个月的咽痛加重、口腔疼痛、腹泻、体重减轻以及盗汗和疲劳等全身症状。根据病理结果，该患者最终被诊断为口腔卡波西肉瘤。该病例突出了卡波西肉瘤作为晚期HIV/AIDS潜在初始表现的情况以及早期识别和治疗的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de39/12221191/65cf9b17bdba/cureus-0017-00000085243-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de39/12221191/59ea1e269062/cureus-0017-00000085243-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de39/12221191/65cf9b17bdba/cureus-0017-00000085243-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de39/12221191/59ea1e269062/cureus-0017-00000085243-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de39/12221191/65cf9b17bdba/cureus-0017-00000085243-i02.jpg

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本文引用的文献

1
A case of Kaposi's sarcoma of tonsil with profuse bleeding in an HIV-positive patient.一名HIV阳性患者发生扁桃体卡波西肉瘤并伴有大量出血的病例。
SAGE Open Med Case Rep. 2021 Dec 22;9:2050313X211066411. doi: 10.1177/2050313X211066411. eCollection 2021.
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AIDS-Related Kaposi Sarcoma, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.艾滋病相关卡波西肉瘤，版本 2.2019，NCCN 肿瘤学临床实践指南。
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Oral Kaposi Sarcoma.口腔卡波西肉瘤
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Kaposi's sarcoma in HIV-infected patients in the era of new antiretrovirals.新型抗逆转录病毒药物时代的 HIV 感染者中的卡波西肉瘤。
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Oral Kaposi's sarcoma: Sole presentation in HIV seropositive patient.口腔卡波西肉瘤：HIV血清阳性患者的唯一表现。
J Nat Sci Biol Med. 2015 Jul-Dec;6(2):459-61. doi: 10.4103/0976-9668.160041.
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Kaposi sarcoma: review and medical management update.卡波西肉瘤：综述及医疗管理更新。
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Jan;113(1):2-16. doi: 10.1016/j.tripleo.2011.05.011. Epub 2011 Sep 1.
8
Oral HIV-associated Kaposi sarcoma.口腔艾滋病相关性卡波西肉瘤。
J Oral Pathol Med. 2013 Mar;42(3):201-7. doi: 10.1111/j.1600-0714.2012.01180.x. Epub 2012 Jun 5.
9
HIV-associated Kaposi sarcoma: pathogenic mechanisms.人类免疫缺陷病毒相关的卡波西肉瘤：致病机制
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Oct;104(4):521-9. doi: 10.1016/j.tripleo.2006.08.015.
10
AIDS-related Kaposi's Sarcoma: evaluation of potential new prognostic factors and assessment of the AIDS Clinical Trial Group Staging System in the Haart Era--the Italian Cooperative Group on AIDS and Tumors and the Italian Cohort of Patients Naive From Antiretrovirals.艾滋病相关卡波西肉瘤：在高效抗逆转录病毒治疗时代评估潜在的新预后因素及艾滋病临床试验组分期系统——意大利艾滋病与肿瘤合作组及意大利未接受过抗逆转录病毒治疗患者队列
J Clin Oncol. 2003 Aug 1;21(15):2876-82. doi: 10.1200/JCO.2003.10.162.