Bradshaw Tyler J, Brosch-Lenz Julia, Uribe Carlos, Karakatsanis Nicolas, Bruce Richard, Strigari Lidia, Jha Abhinav, Dutta Joyita, Schwartz Jazmin, El Fakhri Georges, Avval Atlas, Rahmim Arman, Saboury Babak
Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin;
Institute of Nuclear Medicine, Bethesda, Maryland.
J Nucl Med. 2025 Sep 2;66(9):1471-1479. doi: 10.2967/jnumed.124.269424.
There is a pressing need for improved standardization of terminology and data in nuclear medicine. The field is experiencing unprecedented growth, driven by advances in radiopharmaceutical therapy (RPT) and the emergence of artificial intelligence (AI). However, there are challenges that threaten to frustrate this continued progress. For instance, despite the successes of RPT, high-quality evidence on how to best personalize RPT and take full advantage of its theranostics properties is still lacking. To obtain this evidence, large, structured datasets are needed to associate different RPT strategies with patient outcomes. Large datasets are also needed for the development of AI algorithms, especially as new foundation models demand increasingly large training datasets. Both of these obstacles could be overcome by multiinstitutional data sharing. However, inconsistencies in terminology and data collection make effective data pooling difficult. This article, produced by the Society of Nuclear Medicine and Molecular Imaging AI-Dosimetry Working Group, discusses the need for standardization in nuclear medicine terminology and data. We advocate for the adoption of standardized data and metadata frameworks based on controlled biomedical ontologies to better harmonize the collection of nuclear medicine data. We provide recommendations for the field that, if followed, would facilitate multiinstitutional data sharing and allow for the collection of large datasets. We describe a use case demonstrating how standardized vocabularies and data collection can enhance efforts to associate theranostics target expression data with patient outcomes.
核医学领域迫切需要改进术语和数据的标准化。在放射性药物治疗(RPT)的进展和人工智能(AI)的出现推动下,该领域正经历前所未有的增长。然而,存在一些挑战可能会阻碍这一持续进展。例如,尽管RPT取得了成功,但关于如何最好地实现RPT个性化并充分利用其诊疗特性的高质量证据仍然缺乏。为了获得这一证据,需要大型结构化数据集来将不同的RPT策略与患者预后相关联。开发人工智能算法也需要大型数据集,特别是随着新的基础模型对训练数据集的需求越来越大。通过多机构数据共享可以克服这两个障碍。然而,术语和数据收集的不一致使得有效的数据汇总变得困难。本文由核医学与分子影像学会人工智能剂量学工作组撰写,讨论了核医学术语和数据标准化的必要性。我们主张采用基于受控生物医学本体的标准化数据和元数据框架,以更好地协调核医学数据的收集。我们为该领域提供了建议,如果遵循这些建议,将有助于多机构数据共享,并允许收集大型数据集。我们描述了一个用例,展示了标准化词汇和数据收集如何能够加强将诊疗靶点表达数据与患者预后相关联的工作。