Almasri Dana, Dahman Yaser
Department of Electrical, Computer & Biomedical Engineering, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.
Department of Chemical Engineering, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.
Int J Mol Sci. 2025 Jul 7;26(13):6524. doi: 10.3390/ijms26136524.
This study investigates the use of a salt template to synthesize mesoporous bioactive glass (MBG). Different salts were used as hard templates to create pores in the glass structure to investigate the possibility of using acid-soluble salt templates and to understand the properties of glass synthesized without thermal treatment. The MBGs were synthesized in a TRIS buffer solution at a pH of 9.5 to allow hydrolysis of the metal oxide precursors. The glass was then washed with mild acid to remove the template. After the samples were washed, some were subjected to thermal treatment, while others were not to investigate the impact of thermal treatment on the structure of the MBG. The successful synthesis of MBG was confirmed by X-ray diffraction, Fourier-transfer infrared spectroscopy, scanning emission scanning microscope, and nitrogen adsorption-desorption analysis. This synthesized MBG had a large surface area, pore volume, pore size, and high drug loading efficiency. MBG synthesized without thermal treatment had slower degradation over the test period, but higher loading efficiency and slower drug release, making it appropriate for applications requiring long-term drug delivery while maintaining its bioactivity.
本研究考察了使用盐模板合成介孔生物活性玻璃（MBG）的情况。使用不同的盐作为硬模板在玻璃结构中制造孔隙，以研究使用酸溶性盐模板的可能性，并了解未经热处理合成的玻璃的性能。MBG在pH为9.5的TRIS缓冲溶液中合成，以使金属氧化物前驱体发生水解。然后用弱酸洗涤玻璃以去除模板。样品洗涤后，一些进行热处理，另一些不进行热处理，以研究热处理对MBG结构的影响。通过X射线衍射、傅里叶变换红外光谱、扫描发射扫描显微镜和氮吸附-脱附分析证实了MBG的成功合成。这种合成的MBG具有较大的表面积、孔体积、孔径和较高的载药效率。未经热处理合成的MBG在测试期间降解较慢，但载药效率较高且药物释放较慢，这使其适用于需要长期药物递送同时保持其生物活性的应用。
