对感染落基山斑疹热的恒河猴的研究。
Studies on Macaca mulatta infected with Rocky Mountain spotted fever.
作者信息
Sammons L S, Kenyon R H, Burger G T, Beisel W R, Pedersen C E
出版信息
Am J Vet Res. 1977 Jun;38(6):907-10.
Acid-base alterations and changes in other selected serum constituents (free fatty acids, triglycerides, cholesterol, copper, cortisol, alpha1-acid glycoprotein, haptoglobin, and albumin) were measured during a study of Rocky Mountain spotted fever in 16 male rhesus macaques. Blood samples were taken from nonanesthetized macaques conditioned to repeated handling. Arterial pH increased and PCO2 decreased during the febrile period. Free fatty acids, triglycerides, copper, cortisol, alpha1-acid glycoprotein, and haptoglobin increased, whereas albumin decreased during the disease. Significant changes were not observed in arterial PO2. Cholesterol remained unchanged. The increase in arterial pH and decrease in PaCO2 indicated that respiratory alkalosis was present in macaques acutely affected with Rocky Mountain spotted fever.
在一项对16只雄性恒河猴进行的落基山斑疹热研究中，对酸碱变化以及其他选定血清成分（游离脂肪酸、甘油三酯、胆固醇、铜、皮质醇、α1-酸性糖蛋白、触珠蛋白和白蛋白）的变化进行了测量。血液样本取自适应反复处理的未麻醉猕猴。发热期动脉pH值升高，PCO2降低。疾病期间，游离脂肪酸、甘油三酯、铜、皮质醇、α1-酸性糖蛋白和触珠蛋白增加，而白蛋白减少。动脉PO2未观察到显著变化。胆固醇保持不变。动脉pH值升高和PaCO2降低表明，急性感染落基山斑疹热的猕猴存在呼吸性碱中毒。
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