Li Zheng, Chen Miao-Hua, Wu Qing-Qing, Yuan Cheng, Xu Jing-Juan, Chen Hong-Yuan, Zhao Wei-Wei
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Natl Sci Rev. 2025 May 23;12(7):nwaf213. doi: 10.1093/nsr/nwaf213. eCollection 2025 Jul.
The demand for deep human-machine fusion propels the development of artificial neurons. However, emulating the neuronal spiking in aqueous environments remains challenging. Metal-organic frameworks (MOFs) have recently shown promise in neuromorphic engineering compatible with aqueous operation. Here, we report a MOF neuron with real neurotransmitter-dopamine (DA)-tunable spikes for the first time. Based on the DA mediation, some sophisticated neuronal functions, including integration-and-firing, synaptic facilitation-induced spike broadening and DA-tunable spiking number and width, were mimicked. DA-mediated spikes in this MOF neuron were further implemented to exquisitely control peripheral equipment. This work introduces the concept of a MOF neuron interfaced with a real neurotransmitter in fluids, providing a new perspective for artificial neuron development.
对深度人机融合的需求推动了人工神经元的发展。然而，在水性环境中模拟神经元的尖峰放电仍然具有挑战性。金属有机框架（MOF）最近在与水性操作兼容的神经形态工程中显示出前景。在此，我们首次报道了一种具有可由真实神经递质多巴胺（DA）调节尖峰的MOF神经元。基于DA介导，模拟了一些复杂的神经元功能，包括整合与放电、突触易化诱导的尖峰展宽以及DA可调的尖峰数量和宽度。该MOF神经元中DA介导的尖峰进一步用于精确控制外围设备。这项工作引入了在流体中与真实神经递质连接的MOF神经元的概念，为人工神经元的发展提供了新的视角。
