Wilkins E G, Ratcliffe J G, Roberts C
J Clin Pathol. 1985 Dec;38(12):1342-5. doi: 10.1136/jcp.38.12.1342.
The value of the one minute leucocyte esterase-nitrite chemical strips as a screening procedure for detecting appreciable levels of pyuria and bacteriuria was assessed by comparison with microscopy and culture results. The likelihood that a negative leucocyte esterase result indicated less than 10 white cells/cu mm by microscopy (the negative predictive value), was 90.1% and that a negative nitrite result indicated less than 10(5) organisms/ml was 91.3%. There were many false positive results with both tests, however, and the overall predictive value of a positive leucocyte esterase or nitrite test, or both, was low. The leucocyte esterase-nitrite strip was neither sufficiently sensitive nor specific enough to be used as a cost effective method for screening urines in the laboratory.
通过与显微镜检查和培养结果相比较，评估了一分钟白细胞酯酶-亚硝酸盐化学试纸作为检测明显脓尿和菌尿水平的筛查程序的价值。白细胞酯酶结果为阴性表明显微镜检查白细胞少于10个/立方毫米（阴性预测值）的可能性为90.1%，亚硝酸盐结果为阴性表明细菌少于10⁵个/毫升的可能性为91.3%。然而，两种检测都有许多假阳性结果，白细胞酯酶或亚硝酸盐检测或两者均为阳性的总体预测价值较低。白细胞酯酶-亚硝酸盐试纸既不够敏感也不够特异，不能作为实验室尿液筛查的经济有效方法。
