Liu Junjun, Wang Wenjun
Department of Respiratory and Critical Care Medicine, The Affiliated Hospital Southwest Medical University Luzhou Sichuan China.
Inflammation & Allergic Diseases Research Unit, The Affiliated Hospital Southwest Medical University Luzhou Sichuan China.
Pulm Circ. 2025 Aug 20;15(3):e70154. doi: 10.1002/pul2.70154. eCollection 2025 Jul.
Pulmonary arterial hypertension (PAH) is a common condition among women of childbearing age (WCBA) and is associated with adverse outcomes during pregnancy. However, there is currently a lack of studies that provide a detailed epidemiological characterization of this condition. This study aimed to delineate the global burden of pulmonary arterial hypertension (PAH) among women of childbearing age (WCBA) from 1990 to 2021. We utilized the Global Burden of Disease Study 2021 to estimate the prevalence, incidence, mortality, and disability-adjusted life years (DALYs) for PAH among WCBA across 204 countries and territories from 1990 to 2021. Sociodemographic index (SDI) was used to assess the impact of socioeconomic development on PAH burden. In 2021, global estimates revealed 46,630 prevalent cases of PAH, resulting in 8532 new cases, 1777 deaths and 103,151 DALYs. Globally, the age-standardized prevalence, incidence, mortality, and DALY rates for PAH in 2021 stood at 2.35, 0.43, 0.09, and 5.26 per 100,000 population, respectively. In 2021, Switzerland exhibited the highest age-standardized prevalence rate (7.47/100,000). The highest age-standardized incidence rate was observed in Zambia (0.96/100,000). Mauritius reported the highest age-standardized mortality (0.72/100,000) and DALY rates (40.42/100,000), contrasting sharply with Moldova's lowest rates (0.00/100,000 and 0.51/100,000, respectively). At the regional level, the relationship between the SDI and age-standardized prevalence rates for PAH exhibited an approximate V-shaped pattern. The systematic analysis of PAH burden among WCBA underscores the disease's significant global impact and the necessity for continued research and tailored public health strategies, calling for enhanced awareness, improved diagnostics, and more effective treatment modalities, particularly in resource-constrained settings.
肺动脉高压（PAH）在育龄女性中较为常见，且与孕期不良结局相关。然而，目前缺乏对该疾病进行详细流行病学特征描述的研究。本研究旨在描绘1990年至2021年全球育龄女性肺动脉高压（PAH）的负担情况。我们利用《2021年全球疾病负担研究》来估计1990年至2021年期间204个国家和地区育龄女性PAH的患病率、发病率、死亡率和伤残调整生命年（DALYs）。社会人口学指数（SDI）用于评估社会经济发展对PAH负担的影响。2021年，全球估计显示有46,630例PAH现患病例，新增病例8532例，死亡1777例，DALYs为103,151例。全球范围内，2021年PAH的年龄标准化患病率、发病率、死亡率和DALY率分别为每10万人2.35例、0.43例、0.09例和5.26例。2021年，瑞士的年龄标准化患病率最高（7.47/10万）。赞比亚的年龄标准化发病率最高（0.96/10万）。毛里求斯报告的年龄标准化死亡率（0.72/10万）和DALY率（40.42/10万）最高，与摩尔多瓦的最低率（分别为0.00/10万和0.51/10万）形成鲜明对比。在区域层面，SDI与PAH年龄标准化患病率之间的关系呈现出近似的V形模式。对育龄女性PAH负担的系统分析强调了该疾病对全球的重大影响，以及持续研究和制定针对性公共卫生策略的必要性，呼吁提高认识、改善诊断并采用更有效的治疗方式，特别是在资源有限的环境中。
