Digital transformation has been one of the main trends in organizations in recent years, and digital literacy is a critical factor in the success of this transformation. Digital transformation involves the use of digital technologies to improve an organization's processes, products, and services. For this transformation to be successful, it is necessary for employees to have knowledge of and skills in digital technologies. Digital literacy allows employees to understand technologies and their applications, know how to use them efficiently and safely, evaluate and select the most appropriate digital tools for each task, and be prepared to deal with problems and challenges that arise in the digital environment. This study investigates the relationship between digital transformation and digital literacy through a Systematic Literature Review conducted in accordance with Kitchenham's guidelines. A total of 54 articles, published from 2018, were analyzed from databases such as Scopus, Science Direct, IEEE and Springer. The results reveal that digital literacy significantly influences the success of digital transformation, particularly in areas such as employee adaptability, innovation capacity, and digital tool integration. Key mediating and moderating factors identified include organizational learning culture, leadership support, ongoing training programs, and technological infrastructure. Based on these findings, an explanatory model was developed that maps the interaction between these variables and their impact on digital transformation outcomes. The study offers practical implications for organizations seeking to enhance their digital maturity: investing in employee digital literacy development, aligning leadership strategies with digital initiatives, and fostering a supportive culture for digital adoption are crucial steps. Thus, this study is relevant because it seeks to understand how digital literacy can impact Digital Transformation in organizations and, through the construction of an explanatory model, allows the identification of variables that influence this relationship by developing strategies to improve the digital literacy of employees in organizations.