Hatsukami D K, Hughes J R, Pickens R W
Addict Behav. 1985;10(4):413-7. doi: 10.1016/0306-4603(85)90038-3.
The relationship between tobacco withdrawal symptoms and pre- and post-cigarette blood nicotine levels, pre-cigarette cotinine levels, change in nicotine level from pre- to post-cigarette, half-life for nicotine, and total smoke exposure was examined in 20 smokers. Subjects' reports of craving for cigarettes were significantly related to blood nicotine/cotinine levels and change in nicotine level from pre- to post-cigarette; questionnaire measures of confusion and number of awakenings during sleep was related to half-life for nicotine; and number of awakenings during sleep was related to behavioral measures of total smoke exposure. These results suggests some symptoms of tobacco withdrawal are related to nicotine deprivation while others are not.
在20名吸烟者中研究了烟草戒断症状与吸烟前后血液中尼古丁水平、吸烟前可替宁水平、吸烟前后尼古丁水平的变化、尼古丁半衰期以及总吸烟暴露量之间的关系。受试者对香烟的渴望报告与血液中尼古丁/可替宁水平以及吸烟前后尼古丁水平的变化显著相关；问卷中关于困惑和睡眠中觉醒次数的测量与尼古丁半衰期有关；睡眠中觉醒次数与总吸烟暴露量的行为测量有关。这些结果表明，烟草戒断的一些症状与尼古丁剥夺有关，而其他症状则无关。
