Yin Bo, Zhou Huijuan
Department of Gynecology, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Front Oncol. 2025 Aug 22;15:1647757. doi: 10.3389/fonc.2025.1647757. eCollection 2025.
Ovarian cancer (OC) and uterine cancer (UC) are significant public health concerns among women of reproductive age. High body mass index (BMI) contributes to the increasing burden of these cancers globally, but comprehensive epidemiological assessments remain limited.
Data were obtained from the Global Burden of Disease (GBD) Study 2021 (1990-2021). Deaths, disability-adjusted life-years (DALYs), and corresponding age-standardized rates (ASRs) were calculated to assess disease burden. Burden by age was analyzed in five-year intervals. Differences across Sociodemographic Index (SDI) quintiles were compared. Temporal trends from 1990 to 2021 were assessed using estimated annual percentage change and absolute number changes. Future ASRs were projected to 2036 using a Bayesian age-period-cohort model.
In 2021, an estimated 2,022 (95% uncertainty interval [UI], 473-3,611) deaths and 99,915 (95% UI, 22,387-178,579) DALYs from OC attributable to high BMI occurred among women of reproductive age, with Eastern Europe exhibiting the highest age-standardized mortality rate and DALYs among 21 GBD regions. For UC, there were 2,202 (95% UI, 1,545-2,910) deaths and 114,117 (95% UI, 80,122-150,221) DALYs, with the Caribbean among the regions with the highest burden. From 1990 to 2021, ASRs for mortality and DALYs for both OC and UC attributable to high BMI significantly increased and are projected to continue rising over the next 15 years. The burden increased with age, peaking at 45-49 years. Regionally, burden rose in low- and middle-SDI areas, while high-SDI regions showed initial increases followed by declines.
The rising mortality and DALYs of OC and UC attributable to high BMI, especially in low- and middle-SDI regions and high-burden areas such as Eastern Europe and the Caribbean, highlight an urgent need for targeted prevention and weight management interventions among women of reproductive age.
卵巢癌（OC）和子宫癌（UC）是育龄女性重要的公共卫生问题。高体重指数（BMI）导致全球这些癌症的负担不断增加，但全面的流行病学评估仍然有限。
数据来自《2021年全球疾病负担（GBD）研究》（1990 - 2021年）。计算死亡人数、伤残调整生命年（DALYs）以及相应的年龄标准化率（ASRs）以评估疾病负担。按五年间隔分析年龄别负担。比较社会人口指数（SDI）五分位数之间的差异。使用估计的年度百分比变化和绝对数量变化评估1990年至2021年的时间趋势。使用贝叶斯年龄 - 时期 - 队列模型预测到2036年的未来年龄标准化率。
2021年，育龄女性中估计有2022例（95%不确定区间[UI]，473 - 3611）因高BMI导致的卵巢癌死亡和99915例（95% UI，22387 - 178579）伤残调整生命年，在21个GBD地区中，东欧的年龄标准化死亡率和伤残调整生命年最高。对于子宫癌，有2202例（95% UI，1545 - 2910）死亡和114117例（95% UI，80122 - 150221）伤残调整生命年，加勒比地区是负担最高的地区之一。从1990年到2021年，因高BMI导致的卵巢癌和子宫癌的死亡率年龄标准化率以及伤残调整生命年显著增加，预计在未来15年将继续上升。负担随年龄增加，在45 - 49岁达到峰值。在区域上，低和中等SDI地区的负担上升，而高SDI地区则先上升后下降。
因高BMI导致的卵巢癌和子宫癌死亡率及伤残调整生命年不断上升，特别是在低和中等SDI地区以及东欧和加勒比等高负担地区，凸显了迫切需要对育龄女性进行有针对性的预防和体重管理干预。
