Dong Xinjiang, Wang Jia, Du Jing, Wang Beibei, Li Gang, Yang Jiefu, Zou Tong
Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
School of Public Health, Capital Medical University, Beijing, China.
J Clin Hypertens (Greenwich). 2025 Sep;27(9):e70109. doi: 10.1111/jch.70109.
This study aims to fill this gap by leveraging Global Burden of Disease 2021 (GBD 2021) data to conduct a comprehensive assessment of the disease burden attributable to high systolic blood pressure (SBP) in young adults. Data from the Global Health Data Exchange were utilized to estimate the disease burden attributable to high SBP in young adults, stratified by overall disease, sex, socio-demographic index (SDI) level, GBD region, nation, and specific disease. In 2021, the overall disease attributable to high SBP in young adults was substantial, with approximately 24,626,362 disability-adjusted life years (DALYs) and 477,992 deaths, and the DALYs and mortality rates were 623.68 and 12.11 per 100,000 populations, respectively. The DALYs and mortality rates of specific disease were highest for ischemic heart disease (IHD), followed by intracerebral hemorrhage (ICH), and hypertensive heart disease (HHD). From 1990 to 2021, the DALYs and mortality rates for overall disease attributable to high SBP in young adults showed no significant change.However, there were greater declines in HHD and ICH, while the majority of diseases exhibited an upward trend. The DALYs and mortality rates for overall disease attributable to high SBP in young adults showed no significant change in females but increased in males. The SDI regions like middle and low-middle SDI regions, GBD regions like Oceania and Caribbean, and countries like Lesotho and Zimbabwe presented the largest increases in the DALYs and mortality rates for overall disease attributable to high SBP in young adults. The trends for certain diseases attributable to high SBP in young adults, when analyzed by sex, SDI level, and region, diverge from the overall disease trends. This study highlights the significant overall disease burden attributable to high SBP in young adults. Despite an overall steady trend in the DALYs and mortality rates since 1990, significant disparities persist across overall diseases, sexes, SDI levels, regions, countries, and specific diseases. These disparities highlight the need for strategic interventions to reduce the health impact of high SBP in young adults.
本研究旨在通过利用《2021年全球疾病负担》（GBD 2021）数据，对年轻成年人中高收缩压（SBP）所致疾病负担进行全面评估，以填补这一空白。利用全球卫生数据交换所的数据，按总体疾病、性别、社会人口指数（SDI）水平、GBD区域、国家和特定疾病对年轻成年人中高SBP所致疾病负担进行估计。2021年，年轻成年人中高SBP所致总体疾病负担巨大，约有24626362伤残调整生命年（DALYs）和477992例死亡，DALYs率和死亡率分别为每10万人623.68和12.11。特定疾病的DALYs率和死亡率以缺血性心脏病（IHD）最高，其次是脑出血（ICH）和高血压性心脏病（HHD）。1990年至2021年，年轻成年人中高SBP所致总体疾病的DALYs率和死亡率无显著变化。然而，HHD和ICH的下降幅度更大，而大多数疾病呈上升趋势。年轻成年人中高SBP所致总体疾病的DALYs率和死亡率在女性中无显著变化，但在男性中有所增加。中低SDI地区等SDI地区、大洋洲和加勒比等GBD地区以及莱索托和津巴布韦等国家，年轻成年人中高SBP所致总体疾病的DALYs率和死亡率增幅最大。按性别、SDI水平和地区分析时，年轻成年人中某些高SBP所致疾病的趋势与总体疾病趋势不同。本研究强调了年轻成年人中高SBP所致的重大总体疾病负担。尽管自1990年以来DALYs率和死亡率总体呈稳定趋势，但在总体疾病、性别、SDI水平、地区、国家和特定疾病方面仍存在显著差异。这些差异凸显了采取战略干预措施以减少高SBP对年轻成年人健康影响的必要性。
