苏木和螺旋藻对乙醇诱导的实验性大鼠胃炎模型的保护作用研究。
Investigation of the protective efficacy of Caesalpinia sappan and spirulina against ethanol-induced experimental rat gastritis model.
作者信息
Oruç İdris, Karakoç Zelal, Akduman Filiz, Oruç Zeynep, Baksi Nazan, Ketani Muzaffer Aydin
机构信息
Dicle University - Department of Nephrology - Diyarbakir - Turkey.
Dicle University - Department of Clinical Biochemistry - Diyarbakir - Turkey.
出版信息
Acta Cir Bras. 2025 Sep 19;40:e406725. doi: 10.1590/acb406725. eCollection 2025.
PURPOSE
To evaluate the protective effect of Caesalpinia sappan and spirulina against gastritis and determine changes in the expression of CD8, CD68, and major histocompatibility complex (MHC) molecules.
METHODS
Gastritis was induced in 24 female Wistar albino rats on the first day using ethanol. The treatment groups were given C. sappan (250 mg/kg) and spirulina (400 mg/kg) using oral gavage for five days. Blood and stomach tissue samples of the mice were analyzed.
RESULTS
Caesalpinia sappan and spirulina increased CD8 and CD68 expression and tumor necrosis factor-alpha levels thereby decreasing the severity of inflammation. It was found that they simultaneously decreased MHC I and MHC II expressing cells, increased superoxide dismutase levels, whereas malondialdehyde, and myeloperoxidase levels decreased in the treatment group.
CONCLUSION
This study revealed that C. sappan and spirulina can protect gastric mucosa by reducing oxidative stress and inflammation.
目的
评估苏木和螺旋藻对胃炎的保护作用，并确定CD8、CD68和主要组织相容性复合体（MHC）分子表达的变化。
方法
在第一天，用乙醇诱导24只雌性Wistar白化大鼠患胃炎。治疗组通过口服灌胃给予苏木（250毫克/千克）和螺旋藻（400毫克/千克），持续五天。对小鼠的血液和胃组织样本进行分析。
结果
苏木和螺旋藻增加了CD8和CD68的表达以及肿瘤坏死因子-α水平，从而降低了炎症的严重程度。发现它们同时减少了表达MHC I和MHC II的细胞，增加了超氧化物歧化酶水平，而治疗组中的丙二醛和髓过氧化物酶水平降低。
结论
本研究表明，苏木和螺旋藻可通过减轻氧化应激和炎症来保护胃黏膜。
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