Tantayakhom Sirapatsorn, Inpan Ratchanon, Yaja Kantirat, Koonrungsesomboon Nut, Teekachunhatean Supanimit, Na Takuathung Mingkwan
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Clinical Research Center for Food and Herbal Product Trials and Development (CR-FAH), Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Int J Mol Sci. 2025 Sep 17;26(18):9051. doi: 10.3390/ijms26189051.
Rice bran, a fiber-rich source of bioactive compounds, has gained attention for its potential health benefits, yet its effects on metabolic syndrome (MetS) remain unclear. This study aimed to evaluate the impact of rice bran consumption on anthropometric measures, blood pressure, glycemic control, and lipid profiles in individuals with MetS. A systematic search of PubMed/Medline, Scopus, Cochrane Library, and Embase was conducted up to 30 January 2025, to identify randomized controlled trials (RCTs) assessing rice bran supplementation. Twenty-six RCTs involving 1255 participants (642 in rice bran groups, 613 in controls) were included in the meta-analysis. Weighted mean differences (WMDs) with corresponding values were calculated. Rice bran significantly reduced systolic blood pressure (WMD: -3.336 mmHg; = 0.0006), diastolic blood pressure (WMD: -3.145 mmHg; = 0.015), and HbA1c (WMD: -0.199%; = 0.003). Lipid profiles improved, with reductions in total cholesterol (WMD: -13.594 mg/dL; < 0.0001) and LDL cholesterol (WMD: -14.580 mg/dL; < 0.0001), and an increase in HDL cholesterol (WMD: 3.074 mg/dL; = 0.007). These findings suggest rice bran supplementation may be a promising natural dietary strategy for managing and preventing MetS.
米糠是一种富含生物活性化合物的纤维来源，因其潜在的健康益处而受到关注，但其对代谢综合征（MetS）的影响仍不明确。本研究旨在评估食用米糠对患有MetS的个体的人体测量指标、血压、血糖控制和血脂谱的影响。截至2025年1月30日，对PubMed/Medline、Scopus、Cochrane图书馆和Embase进行了系统检索，以识别评估米糠补充剂的随机对照试验（RCT）。荟萃分析纳入了26项RCT，涉及1255名参与者（米糠组642名，对照组613名）。计算了加权平均差（WMD）及相应的 值。米糠显著降低了收缩压（WMD：-3.336 mmHg； = 0.0006）、舒张压（WMD：-3.145 mmHg； = 0.015）和糖化血红蛋白（WMD：-0.199%； = 0.003）。血脂谱得到改善，总胆固醇降低（WMD：-13.594 mg/dL； < 0.0001），低密度脂蛋白胆固醇降低（WMD：-14.580 mg/dL； < 0.0001），高密度脂蛋白胆固醇升高（WMD：3.074 mg/dL； = 0.007）。这些发现表明，补充米糠可能是一种有前景的天然饮食策略，用于管理和预防MetS。
