非球面角膜塑形镜引起的眼轴伸长与角膜屈光力分布变化之间的关联。
Association between axial elongation and corneal power distribution changes induced by aspheric orthokeratology lenses.
作者信息
Li Mengdi, Zhang Kailang, Bi Hua, Guo Xingyi, Li Lihua, Zhang Bin, Yang Xiaoyan
机构信息
Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Hospital Optometric Center, No 4. Gansu Rd, Heping District, Tianjin, 300020, China.
College of Optometry, Nova Southeastern University, 3301 College Avenue, Davie, FL, 33314, USA.
出版信息
Eye Vis (Lond). 2025 Sep 28;12(1):38. doi: 10.1186/s40662-025-00453-1.
PURPOSE
This study investigated how aspheric lens design changes the corneal power distribution and how such changes are associated with the axial elongation in myopic children who underwent orthokeratology.
METHODS
This retrospective study of 116 eyes from children aged 8-13 years were enrolled and fitted with three types of lenses: fully spherical lenses (Alpha, n = 45), those with an aspheric alignment curve (AC) and a spherical base curve (BC) (Dreamlite, n = 37), and lenses with a partly aspheric BC and an aspheric AC (Myok, n = 34). Axial lengths were measured at baseline, 6 and 12 months. Corneal topography maps obtained at baseline and after 1 month of lens wear were analyzed with Fourier decomposition: the F0 (spherical), F1 (asymmetry), F2 (regular astigmatism), and F3 (higher-order irregularity) components were extracted and quantified across ten concentric rings with 0.5 mm width.
RESULTS
The 1-year axial elongation was 0.26 ± 0.21 mm, 0.16 ± 0.19 mm, and 0.10 ± 0.19 mm for the Alpha, Dreamlite, and Myok groups, respectively (P < 0.001). In the 1-month maps, F0 and F1 peaked at the mid-periphery, and declined peripherally. Dreamlite exhibited F0 values greater than those of Alpha (mean difference: 0.02-0.46 D) within the central 2 mm (P < 0.01) and lower than Myok's values (mean difference: 0.66-1.05 D) in the peripheral 3 to 4.5 mm (P < 0.01). Dreamlite also displayed greater F1 compared to Alpha (mean difference: 0.68-0.78 D) within the 1 to 2 mm rings (P < 0.01) but showed no significant difference from Myok. F2 and F3 remained flat and small. Three components, F0, F1, and F3, were negatively associated with axial elongation in these children (P < 0.001).
CONCLUSION
Lenses featuring an aspheric AC resulted in reduced axial elongation and increased spherical power and asymmetry in the central cornea, while lenses with a partly aspherical BC improved spherical power in the mid-periphery. A smaller axial elongation was associated with greater post treatment central cornea asymmetry.
目的
本研究调查了非球面镜片设计如何改变角膜屈光力分布，以及这些变化如何与接受角膜塑形术的近视儿童的眼轴伸长相关。
方法
本回顾性研究纳入了116只8至13岁儿童的眼睛，并为其佩戴三种类型的镜片：全球面镜片（Alpha，n = 45）、具有非球面配适曲线（AC）和球面基弧（BC）的镜片（Dreamlite，n = 37）以及具有部分非球面BC和非球面AC的镜片（Myok，n = 34）。在基线、6个月和12个月时测量眼轴长度。对基线时和佩戴镜片1个月后获得的角膜地形图进行傅里叶分解分析：提取F0（球面）、F1（不对称性）、F2（规则散光）和F3（高阶不规则度）分量，并在十个宽度为0.5 mm的同心环上进行量化。
结果
Alpha、Dreamlite和Myok组的1年眼轴伸长分别为0.26±0.21 mm、0.16±0.19 mm和0.10±0.19 mm（P < 0.001）。在佩戴镜片1个月时的地形图中，F0和F1在中周边区域达到峰值，并向周边递减。Dreamlite在中央2 mm范围内的F0值大于Alpha（平均差值：0.02 - 0.46 D）（P < 0.01），而在周边3至4.5 mm范围内低于Myok的值（平均差值：0.66 - 1.05 D）（P < 0.01）。Dreamlite在1至2 mm环带内的F1也比Alpha大（平均差值：0.68 - 0.78 D）（P < 0.01），但与Myok无显著差异。F2和F3保持平稳且较小。F0、F1和F3这三个分量与这些儿童的眼轴伸长呈负相关（P < 0.001）。
结论
具有非球面AC的镜片可减少眼轴伸长，并增加中央角膜的球面屈光力和不对称性，而具有部分非球面BC的镜片可改善中周边区域的球面屈光力。较小的眼轴伸长与治疗后更大的中央角膜不对称性相关。
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