人类胃肠道和肺部恶性肿瘤中与颗粒相关的RNA指导的DNA聚合酶和高分子量RNA的证据。
Evidence of particle-associated RNA-directed DNA polymerase and high molecular weight RNA in human gastrointestinal and lung malignancies.
作者信息
Cuatico W, Cho J R, Spiegelman S
出版信息
Proc Natl Acad Sci U S A. 1974 Aug;71(8):3304-8. doi: 10.1073/pnas.71.8.3304.
Abstract
Previous communications have demonstrated that neoplastic cells of human breast cancers, leukemias, lymphomas, sarcomas, and brain tumors contain particles with similar diagnostic attributes as those found in RNA oncornaviruses. The present paper concerns malignancies of the gastrointestinal and pulmonary systems for which, like brain tumors, no suitable animal model or corresponding virus exists. By means of the simultaneous detection assay, these tumors have been found to contain 70S RNA and RNA-directed DNA polymerase encapsulated in particulate components possessing densities of 1.16-1.17 g/ml. Twelve out of 17 (70%) colon carcinomas, three out of five (60%) gastric carcinomas, all of three rectal carcinomas, and seven out of ten (70%) lung carcinomas contained detectable levels of these virus-like entities. None of the corresponding normal tissues was positive.
摘要
先前的交流已经证明，人类乳腺癌、白血病、淋巴瘤、肉瘤和脑肿瘤的肿瘤细胞含有与RNA肿瘤病毒中发现的具有相似诊断特征的颗粒。本文关注的是胃肠道和肺部系统的恶性肿瘤，与脑肿瘤一样，这些系统没有合适的动物模型或相应的病毒。通过同步检测试验，发现这些肿瘤含有包裹在密度为1.16 - 1.17 g/ml的颗粒成分中的70S RNA和RNA指导的DNA聚合酶。17例结肠癌中有12例（70%）、5例胃癌中有3例（60%）、3例直肠癌全部、10例肺癌中有7例（70%）含有可检测水平的这些病毒样实体。相应的正常组织均为阴性。
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