小鼠对Semliki森林病毒的迟发型超敏反应。
Delayed-type hypersensitivity against Semliki Forest virus in mice.
作者信息
Kraaijeveld C A, Harmsen M, Khader Boutahar-Trouw B
出版信息
Infect Immun. 1979 Feb;23(2):219-23. doi: 10.1128/iai.23.2.219-223.1979.
Abstract
After intracutaneous immunization with purified inactivated Semliki Forest virus, a delayed-type hypersensitivity without detectable antibodies in serum was obtained in BALB/c mice. Low doses of antigen given intraperitoneally induced antibodies. Intracutaneous immunization with much higher doses induced no specific antibodies, but a footpad swelling was observed after challenge with homolgous antigen. Pretreatment with cyclophosphamide before immunization enhanced footpad swelling. Microscopic examination of footpads from sensitized mice at 24 h after challenge showed a mononuclear infiltrate. The delayed-type reaction could be transferred to syngenic mice with lymph node cells, but not with spleen cells or serum. The biphasic character of the delayed-type hypersensitivity is discussed.
摘要
用纯化的灭活塞姆利基森林病毒进行皮内免疫后，BALB/c小鼠出现了血清中无可检测抗体的迟发型超敏反应。腹腔内注射低剂量抗原则诱导产生抗体。用高得多的剂量进行皮内免疫未诱导产生特异性抗体，但用同源抗原攻击后观察到足垫肿胀。免疫前用环磷酰胺预处理可增强足垫肿胀。攻击后24小时对致敏小鼠的足垫进行显微镜检查显示有单核细胞浸润。迟发型反应可通过淋巴结细胞转移给同基因小鼠，但不能通过脾细胞或血清转移。文中讨论了迟发型超敏反应的双相特征。
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