Caulfield J B, Borg T K
Lab Invest. 1979 Mar;40(3):364-72.
An extensive collagen skeleton in the myocardium is clearly demonstrable by scanning electron microscopy. This system mechanically connects myocytes to contiguous myocytes, connects myocytes to contiguous capillaries, and is responsible for orienting myocytes into anatomical units. The extent and location of the system involves it in a variety of physical parameters of the heart under both normal and abnormal conditions. The myocyte to myocyte collagen struts may provide for sarcomere alignment from cell to cell, ensure equal stretch of contiguous cells, and prevent slippage of adjacent cells. The numerous myocyte to web network connections would ensure that the entire group of cells function in a consistent fashion. The origin and course of the myocyte to capillary collagen struts could account for capillary patency during systole in the presence of high ventricular wall pressures. The complex web network surrounds groups of myocytes and is mechanically coupled to the contained myocytes. The loose collagen connections between groups easily permits slippage and rearrangement of groups of cells as expected in acute dilation. The web network itself could be the site of some of the viscoelastic properties of the heart.
通过扫描电子显微镜可清楚地显示心肌中广泛存在的胶原骨架。该系统将心肌细胞机械地连接到相邻的心肌细胞，将心肌细胞连接到相邻的毛细血管，并负责将心肌细胞排列成解剖单位。该系统的范围和位置使其在正常和异常情况下都参与心脏的各种物理参数。心肌细胞与心肌细胞之间的胶原支柱可实现肌节在细胞间的排列，确保相邻细胞的均匀伸展，并防止相邻细胞滑动。大量心肌细胞与网状网络的连接可确保整个细胞群以一致的方式发挥功能。心肌细胞与毛细血管之间胶原支柱的起源和走向可解释在心室壁压力较高时收缩期毛细血管的通畅情况。复杂的网状网络围绕着心肌细胞群，并与所含的心肌细胞机械耦合。细胞群之间松散的胶原连接很容易允许细胞群如在急性扩张时所预期的那样滑动和重新排列。网状网络本身可能是心脏某些粘弹性特性的所在部位。
