Yang Qingzhen, Xiao Zhanfeng, Lv Xuemeng, Zhang Tingting, Liu Han
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P.R. China.
Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P.R. China.
Int J Bioprint. 2021 Jun 26;7(3):370. doi: 10.18063/ijb.v7i3.370. eCollection 2021.
Heart diseases have become the main killer threatening human health, and various methods have been developed to study heart disease. Among them, heart-on-a-chip has emerged in recent years as a method for constructing disease (or normal) models and is considered as a promising tool to study heart diseases. Compared with other methods, the advantages of heart-on-a-chip include the high portability, high throughput, and the capability to mimic microenvironments . It has shown a great potential in disease mechanism study and drug screening. In this paper, we review the recent advances in heart-on-a-chip, including the fabrication methods (., 3D bioprinting) and biomedical applications. By analyzing the structure of the existing heart-on-a-chip, we proposed that a highly integrated heart-on-a-chip includes four elements: Microfluidic chips, cells/microtissues, microactuators to construct the microenvironment, and microsensors for results readout. Finally, the current challenges and future directions of heart-on-a-chip are discussed.
心脏病已成为威胁人类健康的主要杀手，人们开发了各种方法来研究心脏病。其中，芯片心脏近年来作为一种构建疾病（或正常）模型的方法出现，并被视为研究心脏病的一种有前途的工具。与其他方法相比，芯片心脏的优点包括高便携性、高通量以及模拟微环境的能力。它在疾病机制研究和药物筛选方面显示出巨大潜力。在本文中，我们综述了芯片心脏的最新进展，包括制造方法（如3D生物打印）和生物医学应用。通过分析现有芯片心脏的结构，我们提出一个高度集成的芯片心脏包括四个要素：微流控芯片、细胞/微组织、用于构建微环境的微致动器以及用于结果读出的微传感器。最后，讨论了芯片心脏当前面临的挑战和未来发展方向。
