新西兰小鼠中抗蛋白质抗体的相对亲和力。
Relative affinity of anti-protein antibodies in New Zealand mice.
作者信息
Petty R E, Steward M W
出版信息
Clin Exp Immunol. 1972 Nov;12(3):343-50.
Abstract
New Zealand mice—NZB, NZW and NZB/W F hybrids—were immunized with human serum transferrin in saline. The number of responder animals, levels and relative affinity of the antibody produced to this antigen were determined. Distinct trends in those immunologic parameters were noted with strain, sex and age at immunization. The relative affinity of the antibodies produced by the strains was lower than that previously demonstrated for several other inbred mouse strains. These results are discussed with reference to the spontaneous soluble complex disease developed by the New Zealand mice.
摘要
用盐水中的人血清转铁蛋白对新西兰小鼠（NZB、NZW和NZB/W F杂种小鼠）进行免疫。测定了有反应动物的数量、产生的针对该抗原的抗体水平和相对亲和力。在免疫时，这些免疫学参数在品系、性别和年龄方面呈现出明显的趋势。这些品系产生的抗体的相对亲和力低于先前在其他几个近交小鼠品系中所证明的。结合新西兰小鼠发生的自发性可溶性复合物疾病对这些结果进行了讨论。
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本文引用的文献
1
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Clin Exp Immunol. 1972 Sep;12(1):121-32.
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Cell selection by antigen in the immune response.免疫应答中抗原介导的细胞选择。
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