小鼠中抗体亲和力的遗传控制。
The genetic control of antibody affinity in mice.
作者信息
Katz F E, Steward M W
出版信息
Immunology. 1975 Sep;29(3):543-8.
Random-bred TO mice have been selectively bred into two lines on the basis of the relative affinity (KR) of antibody produced to protein antigens, one line producing high and the other low KR antibody. After four generations of selective breeding the difference in KR between the two lines was highly significant (P less than 0-001). The selection on the basis of KR did not result in a corresponding selection for antibody levels (Abt), which were not significantly different in the two lines. These results indicate that antibody affinity is a genetically controlled parameter of the immune response. Furthermore, this control appears to be expressed by a mechanism which is independent of the amount of antibody produced.
随机繁殖的TO小鼠已根据产生的针对蛋白质抗原的抗体的相对亲和力（KR）被选择性培育成两个品系，一个品系产生高KR抗体，另一个产生低KR抗体。经过四代选择性培育，两个品系之间的KR差异非常显著（P小于0.001）。基于KR的选择并未导致对抗体水平（Abt）的相应选择，两个品系中的抗体水平没有显著差异。这些结果表明，抗体亲和力是免疫反应的一个遗传控制参数。此外，这种控制似乎是由一种独立于所产生抗体量的机制表达的。
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