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1
Studies of adenovirus SV40 hybrid viruses. II. Defectiveness of the hybrid particles.腺病毒SV40杂交病毒的研究。II. 杂交颗粒的缺陷性。
J Exp Med. 1965 Nov 1;122(5):955-66. doi: 10.1084/jem.122.5.955.
2
Studies of adenovirus SV40 hybrid viruses. I. Assay system and further evidence for hybridization.腺病毒SV40杂交病毒的研究。I. 检测系统及杂交的进一步证据。
J Exp Med. 1965 Nov 1;122(5):943-54. doi: 10.1084/jem.122.5.943.
3
Simian virus 40 integration site in an adenovirus 7-simian virus 40 hybrid DNA molecule.猿猴病毒40在腺病毒7-猿猴病毒40杂交DNA分子中的整合位点。
Proc Natl Acad Sci U S A. 1971 May;68(5):1037-41. doi: 10.1073/pnas.68.5.1037.
4
Components of adenovirus-simian virus 40 hybrid viruses.腺病毒-猴病毒40杂交病毒的组成成分。
Proc Natl Acad Sci U S A. 1971 Jul;68(7):1525-9. doi: 10.1073/pnas.68.7.1525.
5
A nondefective (competent) adenovirus-SV40 hybrid isolated from the AD.2-SV40 hybrid population.从AD.2-SV40杂交群体中分离出的一种无缺陷（有活性）的腺病毒-SV40杂交体。
Proc Natl Acad Sci U S A. 1969 Aug;63(4):1128-35. doi: 10.1073/pnas.63.4.1128.
6
Isolation of two plaque variants from the adenovirus type 2-simian virus 40 hybrid population which differ in their efficiency in yielding simian virus 40.从腺病毒2型-猴病毒40杂交群体中分离出两种蚀斑变体，它们产生猴病毒40的效率不同。
J Virol. 1970 Apr;5(4):413-20. doi: 10.1128/JVI.5.4.413-420.1970.
7
Replication in simian cells of defective viruses in an SV40-adenovirus "hybrid" population.SV40-腺病毒“杂交”群体中缺陷病毒在猴细胞中的复制。
J Bacteriol. 1966 Jan;91(1):278-84. doi: 10.1128/jb.91.1.278-284.1966.
8
In vitro transformation by the adenovirus-SV40 hybrid viruses. 3. Morphology of tumors induced with transformed cells.腺病毒 - SV40 杂交病毒的体外转化。3. 转化细胞诱导产生的肿瘤的形态学。
J Exp Med. 1967 Apr 1;125(4):647-56. doi: 10.1084/jem.125.4.647.
9
In vitro transformation by the adenovirus-SV40 hybrid viruses. II. Characteristics of the transformation of hamster cells by the adeno 2-, adeno 3-, and adeno 12-SV40 viruses.腺病毒 - SV40 杂交病毒的体外转化。II. 腺病毒2型、腺病毒3型和腺病毒12型 - SV40病毒对仓鼠细胞的转化特性。
J Exp Med. 1967 Apr 1;125(4):629-46. doi: 10.1084/jem.125.4.629.
10
Biophysical evidence for linkage of adenovirus and SV40 DNA's in adenovirus 7-SV40 hybrid particles.腺病毒7-SV40杂交颗粒中腺病毒与SV40 DNA连接的生物物理证据。
Proc Natl Acad Sci U S A. 1966 Nov;56(5):1509-15. doi: 10.1073/pnas.56.5.1509.

引用本文的文献

1
In vivo evaluation of pathogenicity and transmissibility of influenza A(H1N1)pdm09 hemagglutinin receptor binding domain 222 intrahost variants isolated from a single immunocompromised patient.从一位免疫功能低下患者体内分离的流感 A(H1N1)pdm09 血凝素受体结合域 222 宿主内变异株的致病性和传染性的体内评估。
Virology. 2012 Jun 20;428(1):21-9. doi: 10.1016/j.virol.2012.02.018.
2
Simian virus 40 DNA segment of the adenovirus 7-simian virus 40 hybrid, e46, and its transcription during permissive infection of monkey kidney cells.腺病毒7-猴病毒40杂交体e46的猴病毒40 DNA片段及其在猴肾细胞允许性感染期间的转录。
J Virol. 1975 May;15(5):1214-21. doi: 10.1128/JVI.15.5.1214-1221.1975.
3
Density differences between hybrid and nonhybrid particles in two adenovirus-simian virus 40 hybrid populations.两个腺病毒-猴病毒40杂交群体中杂交颗粒与非杂交颗粒之间的密度差异。
J Virol. 1970 Mar;5(3):353-7. doi: 10.1128/JVI.5.3.353-357.1970.
4
Detection of biologically active adenovirions unable to plaque in human cells.无法在人类细胞中形成噬斑的生物活性腺病毒颗粒的检测。
J Bacteriol. 1966 Aug;92(2):433-8. doi: 10.1128/jb.92.2.433-438.1966.
5
Chinese hamster ovary cells replicate adenovirus deoxyribonucleic acid.中国仓鼠卵巢细胞复制腺病毒脱氧核糖核酸。
Mol Cell Biol. 1981 Mar;1(3):208-15. doi: 10.1128/mcb.1.3.208-215.1981.
6
The adenovirus type 2-simian virus 40 hybrid virus Ad2+ND4 requires deletion variants to grow in monkey cells.腺病毒2型-猴病毒40杂交病毒Ad2+ND4在猴细胞中生长需要缺失变体。
J Virol. 1983 Aug;47(2):344-53. doi: 10.1128/JVI.47.2.344-353.1983.
7
Synthesis of virus deoxyribonucleic acid during abortive infection of simian cells by human adenoviruses.人腺病毒对猴细胞进行流产感染期间病毒脱氧核糖核酸的合成
J Bacteriol. 1966 Oct;92(4):931-6. doi: 10.1128/jb.92.4.931-936.1966.
8
Characteristics of tobacco rattle virus. I. Evidence that its two particles are functionally defective and mutually complementing.烟草脆裂病毒的特性。I. 关于其两种粒子功能有缺陷且相互互补的证据。
Mol Gen Genet. 1968 May 17;101(4):346-67. doi: 10.1007/BF00436232.
9
Production of altered cell foci in tissue culture by defective Moloney sarcoma virus particles.缺陷型莫洛尼肉瘤病毒颗粒在组织培养中产生改变的细胞病灶。
Proc Natl Acad Sci U S A. 1966 Apr;55(4):780-6. doi: 10.1073/pnas.55.4.780.
10
Conditional lethal mutants of adenovirus 2-simian virus 40 hybrids. I. Host range mutants of Ad2+ND1.腺病毒2-猴病毒40杂种的条件致死突变体。I. Ad2+ND1的宿主范围突变体。
J Virol. 1974 Jun;13(6):1237-44. doi: 10.1128/JVI.13.6.1237-1244.1974.

本文引用的文献

1
THE INCORPORATION OF SV40 MATERIAL INTO ADENOVIRUS 7 AS MEASURED BY INTRANUCLEAR SYNTHESIS OF SV40 TUMOR ANTIGEN.通过SV40肿瘤抗原的核内合成来测定SV40物质掺入腺病毒7的情况。
Proc Natl Acad Sci U S A. 1964 Dec;52(6):1348-52. doi: 10.1073/pnas.52.6.1348.
2
EVIDENCE FOR A POSSIBLE GENETIC HYBRID BETWEEN ADENOVIRUS TYPE 7 AND SV40 VIRUSES.7型腺病毒与猿猴空泡病毒40（SV40）之间可能存在基因杂交的证据。
Proc Natl Acad Sci U S A. 1964 Dec;52(6):1340-7. doi: 10.1073/pnas.52.6.1340.
3
INDUCTION BY ADENOVIRUS TYPE 7 OF TUMORS IN HAMSTERS HAVING THE ANTIGENIC CHARACTERISTICS OF SV40 VIRUS.7型腺病毒对具有SV40病毒抗原特性的仓鼠肿瘤的诱导作用
Proc Natl Acad Sci U S A. 1964 Dec;52(6):1333-40. doi: 10.1073/pnas.52.6.1333.
4
ENHANCEMENT OF ADENOVIRUS GROWTH IN AFRICAN GREEN MONKEY KIDNEY CELL CULTURES BY SV40.猴空泡病毒40增强腺病毒在非洲绿猴肾细胞培养物中的生长
Proc Soc Exp Biol Med. 1964 May;116:187-90. doi: 10.3181/00379727-116-29197.
5
The defectiveness of Rous sarcoma virus.劳氏肉瘤病毒的缺陷性
Proc Natl Acad Sci U S A. 1963 Apr;49(4):572-80. doi: 10.1073/pnas.49.4.572.
6
Studies of adenovirus SV40 hybrid viruses. I. Assay system and further evidence for hybridization.腺病毒SV40杂交病毒的研究。I. 检测系统及杂交的进一步证据。
J Exp Med. 1965 Nov 1;122(5):943-54. doi: 10.1084/jem.122.5.943.

腺病毒SV40杂交病毒的研究。II. 杂交颗粒的缺陷性。

Studies of adenovirus SV40 hybrid viruses. II. Defectiveness of the hybrid particles.

作者信息

Rowe W P, Bau S G

出版信息

J Exp Med. 1965 Nov 1;122(5):955-66. doi: 10.1084/jem.122.5.955.

DOI:10.1084/jem.122.5.955
PMID:4285253
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2138111/
Abstract

E46(+) virus purified by limiting dilution and plaque isolation in AGMK cells consists of a mixture of hybrid and non-hybrid virus particles. Of 102 plaque isolates obtained in HEK cells, 98 contained no detectable hybrid virus, while 4 contained a small proportion of hybrid virus. Plaque isolates from AGMK cells uniformly induced SV40 neoantigen, but when these plaque isolates were plaqued in HEK cells the progeny were again non-hybrid adenovirus. It thus appears impossible to obtain a pure line of hybrid virus. The proportion of hybrid virus produced in HEK cells fell progressively with decreasing multiplicity of infection, and plaque induction by E46(+) virus in AGMK followed 2-hit kinetics, indicating that the hybrid virus particles are defective and require dual infection with non-hybrid virus for their propagation.

摘要

通过在非洲绿猴肾（AGMK）细胞中进行有限稀释和空斑分离纯化得到的E46（+）病毒由杂交和非杂交病毒颗粒的混合物组成。在人胚肾（HEK）细胞中获得的102个空斑分离株中，98个未检测到杂交病毒，而4个含有少量杂交病毒。来自AGMK细胞的空斑分离株均能诱导SV40新抗原，但当这些空斑分离株在HEK细胞中进行空斑形成时，子代又变为非杂交腺病毒。因此，似乎不可能获得纯系杂交病毒。在HEK细胞中产生的杂交病毒比例随着感染复数的降低而逐渐下降，并且E46（+）病毒在AGMK细胞中的空斑诱导遵循双打击动力学，这表明杂交病毒颗粒存在缺陷，需要与非杂交病毒双重感染才能增殖。