卵磷脂双分子层中弯曲的脂肪酸链。
Bent fatty acid chains in lecithin bilayers.
作者信息
McFarland B G, McConnell H M
出版信息
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1274-8. doi: 10.1073/pnas.68.6.1274.
Abstract
An analysis of the paramagnetic resonance spectra of a number of phospholipid spin labels in multi-lamellar arrays of lecithin bilayers has been carried out in terms of a distribution of label orientations, and the amplitude and time dependence of high-frequency random motions about these orientations. This analysis indicates that there is a long-lived (>10(-8) sec) average bending of the fatty acid chains such that near the polar head groups the chains are comparatively rigid and tilted at about 30 degrees relative to a normal to the bilayer plane, whereas near the terminal methyl groups the chains are flexible and on the average parallel to this normal. This bent conformation of the chains permits the packing of chains into planar lamellar arrays even when different segments of the chain have different motional freedom.
摘要
对卵磷脂双层多片层阵列中多种磷脂自旋标记的顺磁共振谱进行了分析，该分析基于标记取向的分布以及围绕这些取向的高频随机运动的幅度和时间依赖性。该分析表明，脂肪酸链存在长寿命（>10^(-8) 秒）的平均弯曲，使得在极性头部基团附近，链相对刚性且相对于双层平面法线倾斜约30度，而在末端甲基附近，链是柔性的且平均平行于该法线。即使链的不同部分具有不同的运动自由度，链的这种弯曲构象也允许链堆积成平面片层阵列。
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