Johnson C J, Peterson D R, Smith E K
Am J Clin Nutr. 1979 May;32(5):967-70. doi: 10.1093/ajcn/32.5.967.
Optimum tissue levels of magnesium and potassium ions are essential to the structure and function of the myocardium. We hypothesized that an inapparent deficiency of one or both of these elements might contribute to sudden cardiac death in a susceptible person, and in this study investigated levels of these elements in the myocardium of men experiencing sudden death to determine if there was such an association. Subjects dying suddenly with ischemic heart disease had significantly lower levels of myocardial tissue magnesium and potassium than the controls (men dying of acute trauma). The four lowest potassium values were obtained for the only men in the group with a history of angina (P less than 0.0005). Three of the men with angina also had the lowest tissue magnesium levels (P less than 0.005). The intriguing finding gives support to the hypothesis.
镁离子和钾离子的最佳组织水平对心肌的结构和功能至关重要。我们推测，这些元素中的一种或两种的隐性缺乏可能导致易感人群的心脏性猝死，并且在本研究中调查了猝死男性心肌中这些元素的水平，以确定是否存在这种关联。死于缺血性心脏病的受试者心肌组织镁和钾的水平显著低于对照组（死于急性创伤的男性）。该组中唯一有心绞痛病史的男性钾值最低（P<0.0005）。三名患有心绞痛的男性组织镁水平也最低（P<0.005）。这一有趣的发现支持了该假设。
