由鼠肉瘤病毒转化的非产生细胞系的突变体。I. 诱导、分离、颗粒产生及致瘤性。
Mutants of nonproducer cell lines transformed by murine sarcoma viruses. I. Induction, isolation, particle production, and tumorigenicity.
作者信息
Hatanaka M, Klein R, Toni R, Walker J, Gilden R
出版信息
J Exp Med. 1973 Aug 1;138(2):356-63. doi: 10.1084/jem.138.2.356.
Abstract
A variety of cell mutants were obtained by a single 5'-bromodeoxyuridine (BrdU) treatment of an nonproducer (NP) cell line transformed by the Kirsten strain of murine sarcoma virus (Ki-MSV). Isolation procedures of these cell See PDF for Structure mutants are described. The cell mutants obtained were classified by tumorigenic potential and shedding of Type C virus particles. The cell mutants were classified into four groups: (A) tumorigenic, without particles; (B) tumorigenic, with Type C particles; (C) nontumorigenic, without particles; and (D) nontumorigenic, with Type C particles. The tumorigenic cell lines showed variability in morphology with both flat and typical transformed appearing cell lines showing equal transplantability.
摘要
通过用5'-溴脱氧尿苷（BrdU）单次处理由 Kirsten 株鼠肉瘤病毒（Ki-MSV）转化的非生产性（NP）细胞系，获得了多种细胞突变体。描述了这些细胞突变体的分离程序。所获得的细胞突变体根据致瘤潜力和C型病毒颗粒的释放进行分类。细胞突变体分为四组：（A）致瘤，无颗粒；（B）致瘤，有C型颗粒；（C）非致瘤，无颗粒；（D）非致瘤，有C型颗粒。致瘤细胞系在形态上表现出变异性，扁平型和典型转化型细胞系的移植能力相同。
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