Foster L J, Trudeau W L, Goldman A L
JAMA. 1979 Jun 15;241(24):2613-5.
Nine patients with chronic obstructive pulmonary disease were given oral aminophylline, intravenous aminophylline, and various inhaled and oral adrenergic bronchodilators to determine the effect of these agents on gastric acid secretion and gastrin release. Inhaled epinephrine hydrochloride resulted in an increase in basal acid output of borderline significance (.05 less than P less than .10). Oral aminophylline caused a significant increase in basal acid output from 2.43 to 4.06 mEq (P less than .05). Intravenous aminophylline also caused a significant increase in basal acid output from 0.66 to 2.19 mEq (P less than .01). There were no statistically significant changes in serum gastrin levels after administration of any of the bronchodilators. Aminophylline should be used with caution, if at all, in patients with peptic ulcer disease. In these patients, a beta agonist should be used for initial therapy. If the addition of aminophylline is necessary, antacids should be given.
对9名慢性阻塞性肺疾病患者给予口服氨茶碱、静脉注射氨茶碱以及各种吸入和口服的肾上腺素能支气管扩张剂，以确定这些药物对胃酸分泌和胃泌素释放的影响。吸入盐酸肾上腺素导致基础酸排出量增加，差异具有临界显著性（0.05＜P＜0.10）。口服氨茶碱使基础酸排出量从2.43显著增加至4.06 mEq（P＜0.05）。静脉注射氨茶碱也使基础酸排出量从0.66显著增加至2.19 mEq（P＜0.01）。给予任何一种支气管扩张剂后，血清胃泌素水平均无统计学上的显著变化。患有消化性溃疡疾病的患者应谨慎使用氨茶碱，若要使用也应极为小心。对于这些患者，应使用β受体激动剂进行初始治疗。若有必要加用氨茶碱，则应给予抗酸剂。
