Bodey G P, Valdivieso M, Feld R, Rodriguez V
Antimicrob Agents Chemother. 1974 May;5(5):508-12. doi: 10.1128/AAC.5.5.508.
Amikacin is a new aminoglycoside antibiotic which is active in vitro against most isolates of gram-negative bacilli. A dose of 300 mg/m(2) intramuscularly produced a highest mean serum concentration of 25.4 mug/ml with a mean serum concentration of 3.1 mug/ml at 8 h. The same dose intravenously produced a highest mean serum concentration of 52.4 mug/ml with a mean serum concentration of 2.1 mug/ml at 8 h. The mean urinary excretion during the first 6 h was 75 and 66%, respectively. When amikacin was administered at a dose of 150 mg/m(2) every 6 h, there was evidence of some drug accumulation. A loading dose of 150 mg/m(2) administered intravenously over 30 min followed by 200 mg/m(2) administered as a continuous infusion every 6 h maintained serum concentrations of 8 mug/ml. No major toxicity was observed with any of these drug regimens.
阿米卡星是一种新型氨基糖苷类抗生素，在体外对大多数革兰氏阴性杆菌分离株具有活性。300mg/m²的肌肉注射剂量产生的最高平均血清浓度为25.4μg/ml，8小时时的平均血清浓度为3.1μg/ml。相同剂量静脉注射产生的最高平均血清浓度为52.4μg/ml，8小时时的平均血清浓度为2.1μg/ml。前6小时的平均尿排泄率分别为75%和66%。当每6小时以150mg/m²的剂量给予阿米卡星时，有药物蓄积的迹象。静脉注射150mg/m²的负荷剂量，持续30分钟，然后每6小时以200mg/m²的剂量持续输注，可维持血清浓度为8μg/ml。这些药物方案均未观察到重大毒性。
