小鼠胸腺中不携带θ抗原的细胞的免疫球蛋白合成与分泌。
Immunoglobulin synthesis and secretion by cells in the mouse thymus that do not bear theta antigen.
作者信息
Vitetta E S, Uhr J W, Boyse E A
出版信息
Proc Natl Acad Sci U S A. 1973 Mar;70(3):834-8. doi: 10.1073/pnas.70.3.834.
Abstract
The mouse thymus contains cells that synthesize and secrete minute amounts of immunoglobulin (Ig). These cells were studied by a combination of cytotoxic tests (with alloantisera prepared in congenic strains of mice) followed by pulse labeling of the surviving cell population with [(3)H]tyrosine. The immunoglobulin-synthesizing cells constitute less than 2% of the total cell population and are theta(-), TL(-), Ly-B(-), Ig(+), H-2(+), and PC(+). Since this phenotype is not characteristic of cells of the thymocyte lineage, the Ig(+) cells are probably plasma cells and/or bone marrow-derived (B) lymphocytes. Similar studies of spleen cells indicate that immunoglobulin-synthesizing and secreting cells are theta(-).
摘要
小鼠胸腺含有能合成和分泌微量免疫球蛋白（Ig）的细胞。通过细胞毒性试验（使用在同基因小鼠品系中制备的同种抗血清），然后用[³H]酪氨酸对存活细胞群体进行脉冲标记，对这些细胞进行了研究。免疫球蛋白合成细胞占总细胞群体的比例不到2%，且为θ⁻、TL⁻、Ly - B⁻、Ig⁺、H - 2⁺和PC⁺。由于这种表型并非胸腺细胞谱系细胞的特征，Ig⁺细胞可能是浆细胞和/或骨髓来源的（B）淋巴细胞。对脾细胞的类似研究表明，免疫球蛋白合成和分泌细胞为θ⁻。
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