Ferenczy A, Bertrand G, Gelfand M M
Am J Obstet Gynecol. 1979 Jun 1;134(3):297-304. doi: 10.1016/s0002-9378(16)33036-8.
The proliferation kinetics of endometrial regeneration were assessed by tracing nucleoprotein precursor, radiothymidine. Increased isotope uptake occurred by cycle day 3 and was confined to the gland cells of denuded stratum basale (basal layer) and persistent uterine lining, bordering peripheral areas of denudation. This increase resulted in the formation of flattened surface epithelial cells, which initially were devoid of significant deoxyribonucleic acid synthesis. Such alterations are consistent with changes in cells involved in ameboid migration. Maturation of migrating cells was accompanied by a significant rise in labeling indices and replication at cycle days 3 and 4. By cycle day 5, endometrial repair was complete. The findings indicate that, following physiologic loss of stratum functionale, endometrial healing involves both migration and replication of surface cells, which originate from the gland stumps of the residual basal layer and the persistent surface epithelium adjacent to the periphery of denuded endometrium.
通过追踪核蛋白前体放射性胸腺嘧啶核苷来评估子宫内膜再生的增殖动力学。在周期第3天时，同位素摄取增加，且局限于裸露的基底层（基底膜）的腺细胞以及与剥脱周边区域相邻的持续存在的子宫内膜。这种增加导致扁平表面上皮细胞的形成，这些细胞最初缺乏显著的脱氧核糖核酸合成。此类改变与参与阿米巴样迁移的细胞变化一致。迁移细胞的成熟伴随着在周期第3天和第4天时标记指数和复制的显著增加。到周期第5天时，子宫内膜修复完成。这些发现表明，在功能层生理性缺失后，子宫内膜愈合涉及表面细胞的迁移和复制，这些表面细胞源自残留基底层的腺残端以及与裸露子宫内膜周边相邻的持续存在的表面上皮。
