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人类子宫内膜再生的细胞动力学研究。I. 扫描电子显微镜检查

Studies on the cytodynamics of human endometrial regeneration. I. Scanning electron microscopy.

作者信息

Ferenczy A

出版信息

Am J Obstet Gynecol. 1976 Jan 1;124(1):64-74. doi: 10.1016/0002-9378(76)90013-2.

DOI:10.1016/0002-9378(76)90013-2
PMID:1244749
Abstract

Stereoscopic morphologic studies on regenerating cyclic endometrium indicate that endometrial repair lasts 48 hours, beginning between cycle Days 2 to 3 and ending between cycle Days 4 to 5. During this period, endometrial repair is focused on the neoformation of surface epithelium and is initiated only when and where the zona basalis is denuded from the overlying secretory spongiosa. The surface epithelium is derived from a simultaneous proliferation of dual origin: first from the exposed ends of basal glands and second from the persistent and intact surface lining of cornual and isthmic regions, bordering the denuded areas. The lack of estrogen-dependent morphologic alterations (mitosis and ciliogenesis) in the uterine mucosa during the regenerative period suggests that the initial factors and cellular processes operating in endometrial reconstruction are purely a reflection of tissue repair and are independent of cyclic hormonal stimuli.

摘要

对周期性再生子宫内膜的立体形态学研究表明,子宫内膜修复持续48小时,始于月经周期的第2至3天,结束于第4至5天。在此期间,子宫内膜修复集中于表面上皮的重新形成,且仅在基底层从覆盖的分泌性海绵层剥脱的部位开始。表面上皮来源于双重起源的同时增殖:一是来自基底腺的暴露端,二是来自与剥脱区域相邻的子宫角和峡部区域持续完整的表面内膜。再生期子宫黏膜缺乏雌激素依赖性形态学改变(有丝分裂和纤毛形成),这表明子宫内膜重建过程中起作用的初始因素和细胞过程纯粹是组织修复的反映,且独立于周期性激素刺激。

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