Ferenczy A
Am J Obstet Gynecol. 1976 Mar 15;124(6):582-95. doi: 10.1016/0002-9378(76)90059-4.
The morphologic observations made in this study indicate that postmenstrual endometrial resurfacing occurs by proliferation of epithelial cells originating from the stumps of residual basal glands and uterine surface lining, bordering the denuded areas, respectively. Endometrial stromal cells or glands of the residual spongiosa are not involved in uterine surface repair. The mechanism whereby the new surface develops, it is proposed, is by endomitotic division. This contention is supported by the accelerated nuclear DNA and intracytoplasmic RNA synthesis, and absence of mitosis in the newly formed surface epithelial cells. The results indicate, furthermore, that uterine surface reconstruction, which is completed by cycle day 5, is independent of ovarian hormonal stimuli, whereas further endometrial growth, connective tissue remodeling, and metabolic enzyme synthesis are influenced by the gradual increase of preovulatory estrogens.
本研究中的形态学观察表明，月经后子宫内膜的重新上皮化分别通过源自残留基底腺残端和子宫表面衬里（与剥脱区域相邻）的上皮细胞增殖而发生。残留海绵层的子宫内膜间质细胞或腺体不参与子宫表面修复。有人提出，新表面形成的机制是核内有丝分裂。这一观点得到了新形成的表面上皮细胞核DNA和胞浆RNA合成加速以及无有丝分裂现象的支持。此外，结果表明，在周期第5天完成的子宫表面重建独立于卵巢激素刺激，而子宫内膜的进一步生长、结缔组织重塑和代谢酶合成则受排卵前雌激素逐渐增加的影响。
