被动抗体对免疫反应的调节。I. 抗半抗原抗体增强对载体的迟发型超敏反应并抑制对半抗原的抗体合成。
Modulation of the immune response by passive antibodies. I. Anti-hapten antibodies enhanced delayed hypersensitivity to the carrier and depressed antibody synthesis to the hapten.
作者信息
Neveu P J, Borduas A G
出版信息
Int Arch Allergy Appl Immunol. 1975;48(5):698-705. doi: 10.1159/000231357.
The modulating effects of passive antibodies on both delayed hypersensitivity to the carrier and antibody synthesis to carrier and hapten determinants were studied in guinea pigs. Animals were injected with antibodies directed against either the carrier or the hapten prior to immunization with the hapten-carrier conjugate in Freund's complete adjuvant. Anti-hapten antibodies have been shown to have an enhancing effect on delayed hypersensitivity to the carrier and a suppressive effect on antibody synthesis to the hapten. In this experiment, anti-carrier anti-bodies seemed to have had no effect on delayed hypersensitivity to the carrier and on antibody synthesis to the hapten.
在豚鼠中研究了被动抗体对载体迟发型超敏反应以及针对载体和半抗原决定簇的抗体合成的调节作用。在用弗氏完全佐剂中的半抗原-载体结合物免疫之前，给动物注射针对载体或半抗原的抗体。已表明抗半抗原抗体对载体迟发型超敏反应有增强作用，而对针对半抗原的抗体合成有抑制作用。在本实验中，抗载体抗体似乎对载体迟发型超敏反应以及针对半抗原的抗体合成没有影响。
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