Valdimarsson H, Hambleton G, Henry K, McConnell I
Clin Exp Immunol. 1974 Feb;16(2):141-52.
A 3-year-old girl with three severe attacks of extensive skin ulceration and high fever was found to have a defective T-lymphocyte function. In each attack there was a dramatic but temporary recovery following blood transfusion. This was associated with a reversion of skin anergy and restoration of T-lymphocyte function as measured by phytohaemagglutinin (PHA) transformation and sheep red cell rosettes (SRCR). Each remission lasted 2 months. Studies over a period of 2 months after the third transfusion revealed a progressive loss of T-lymphocyte function. The patient was finally injected with a dialysable leucocyte extract. She remained in good health and a rapid normalization of her lymphocyte responses was observed after the injection. The patient has now been symptom-free for 9 months and has required three injections of leucocyte extract. Each injection has markedly improved her T-lymphocyte function.
一名3岁女童出现三次严重的广泛性皮肤溃疡和高热发作，被发现存在T淋巴细胞功能缺陷。每次发作时，输血后都会有显著但短暂的恢复。这与皮肤无反应性的逆转以及通过植物血凝素（PHA）转化和绵羊红细胞玫瑰花结试验（SRCR）测量的T淋巴细胞功能恢复有关。每次缓解持续2个月。第三次输血后2个月的研究显示T淋巴细胞功能逐渐丧失。该患者最终注射了可透析白细胞提取物。注射后她保持健康，淋巴细胞反应迅速恢复正常。该患者现已9个月无症状，共需要注射三次白细胞提取物。每次注射都显著改善了她的T淋巴细胞功能。
