头孢菌素核β-内酰胺键的水解与3-取代基的脱去之间的相关性。
Correlation between hydrolysis of the -lactam bond of the cephalosporin nucleus and expulsion of the 3-substituent.
作者信息
O'Callaghan C H, Kirby S M, Morris A, Waller R E, Duncombe R E
出版信息
J Bacteriol. 1972 Jun;110(3):988-91. doi: 10.1128/jb.110.3.988-991.1972.
Abstract
The hydrolysis of two cephalosporins by three different beta-lactamases has been studied. Each enzyme caused a decrease in ultraviolet absorption, a loss of biological activity, and the release of the leaving group from the 3-position. The changes occurred at the same rate and to the same extent with each enzyme, and it is inferred that the loss of the leaving group is a consequence of, and not a prerequisite for, hydrolysis of the beta-lactam ring.
摘要
研究了三种不同的β-内酰胺酶对两种头孢菌素的水解作用。每种酶都会导致紫外线吸收降低、生物活性丧失以及3位上离去基团的释放。每种酶引起的这些变化速率相同、程度相同，由此推断离去基团的丧失是β-内酰胺环水解的结果而非前提条件。
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